アブストラクト（31巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Experimental Model for Cementogenesis using Dental Follicle
Subtitle　： Selective Proceedings of 37th General Meeting of Kanagawa Odontological Society, 2002
Authors　： Keisuke Handa1, Masahiro Saito1,4, Akira Tsunoda1, Shintaro Hattori2,4, Masato Yamauchi3, Minoru Toyoda2,4, Sadao Sato3, Toshio Teranaka1,4
Authors（kana）　：
Organization　： 1Department of Operative Dentistry and Endodontics, Kanagawa Dental College, 2Prosthodontics, Kanagawa Dental College, 3Orthodontics, Kanagawa Dental College, 4Institute for Frontier Oral Science Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 31
Number　： 1
Page　： 74-76
Year/Month　： 2003 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： Dental follicle is originated from cranial facial neural crest and it is believed to contain of progenitors for cementoblasts, periodontal ligament cells and osteoblasts. To analyze the differentiation potential of dental follicle, tooth root dentin with cementum and dental follicle are removed from developing tooth germ to be transplanted into the subcutaneous tissue of severe combined immunodeficiency (SCID) mice. After four-week transplantation, extensive amount of cementum matrix was formed between root dentin and dental follicle in the transplant. The newly formed cementum was became almost 20 folds ticker than the previously deposited cementum on root surface, and it was strongly positive for anti-cementum derived attachment protein monoclonal antibody. These results indicated that the cementoblast progenitors were presented in dental follicle, and they are able to differentiate into cementoblast on root surface. Transplantation study of the dental follicle provides a useful model for investigating molecular mechanisms of cementogenesis.
Practice　： Dentistry
Keywords　： Cementogenesis, Dental follicle, Tooth germ, Progenitor, Differentiation