アブストラクト（32巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： The Role of Cell Growth Factors in Saliva, Salivary Glands and Salivary Gland Tumors
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Research Topics from the Research Center of Advanced Technology for Craniomandibular Function in Kanagawa Dental College
Authors　： Keiichi Tsukinoki1), Kentaro Suzuki1), Mayumi Hori1), Kazunari Karakida2), Masanori Yasuda3), Shigeyuki Asano4), Yoshihisa Watanabe1)
Authors（kana）　：
Organization　： 1)Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College, 2)Department of Oral Surgery, Tokai University School of Medicine, 3)Department of Pathology, Tokai University School of Medicine, 4)Division of Pathology, Iwaki Kyouritsu General Hospital
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 32
Number　： 1
Page　： 63-67
Year/Month　： 2004 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] This review focuses on various cell growth factors including the hepatocyte growth factor (HGF) which have important roles in human saliva, salivary glands and salivary gland neoplasms. The effects of HGF, the acceleration or inhibition of cell growth, the enhancement of cell motility, the increase of angiogenesis, and the inhibition of apoptosis as well as the induction of morphogenesis have been demonstrated in various mesenchymal cells. In our recent analysis of HGF regarding saliva, salivary gland and salivary gland neoplasms, we demonstrated the following : that localization of HGF was basically noted in luminal cells of fetal, normal salivary glands and salivary gland neoplasm ; that saliva contains HGF protein by ELISA ; that HGF tends to be more intensely expressed in benign than in malignant salivary gland tumors ; that the HGF-its receptor, c-Met signaling are associated with cell scattering and invasion into the matrix in the adenoid cystic carcinoma cell line ACC3 ; and that the prognosis is poor and is correlated to metastasis in the high grade salivary gland carcinomas with c-Met expression. These profiles imply that HGF may play a significant role in the differentiation or tumor progression of salivary gland neoplasms. We introduced the structure of the salivary gland, the role of cell growth factors in saliva, salivary gland and salivary gland neoplasms.
Practice　： Dentistry
Keywords　： Cell growth factor, HGF, c-Met, Saliva, Salivary gland, Salivary gland neoplasm