アブストラクト（33巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Mandible Bone Regeneration using Bone Morphogenetic Protein
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Current Topics of Tissue Engineering in Dentistry
Authors　： Izumi Asahina
Authors（kana）　：
Organization　： Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 33
Number　： 1
Page　： 21-23
Year/Month　： 2005 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] There have been many attempts to regenerate jawbone defects using new methods that supersede autogenous bone grafts. It is expected that bone morphogenetic proteins (BMPs) will be utilized in bone regeneration. The direct implantation of BMP into bony defects is the easiest way to use BMP. We succeeded in mandible bone regeneration in young primates using this method, and the regenerated bone was maintained and functioned over a period of one year after stress loading. However, the use of BMP in aged monkeys produced inconclusive results. Then, we tried to regenerate bony defects using a combination graft of BMP and osteoprogenitor cells derived from bone marrow. The number of cells was multiplied in a culture, which successfully minimized the donor site morbidity. The results demonstrate that BMP can induce considerable bone even in aged primates by combining BMP-responding cells. Another way to use BMP in bone regeneration is the ex vivo use of BMP. Mesenchymal stem cells or osteoprogenitor cells were cultured in a 3-D scaffold, and BMP was treated during the culture. The treatment of BMP in vitro enhanced bone formation in vivo effectively. Bone regeneration induced by BMPs holds promise as a future therapy and may be an effective alternative to autogenous bone grafts in reconstructive surgery.
Practice　： Dentistry
Keywords　： Mandible bone, Bone regeneration, Bone morphogenetic protein, Tissue engineering