アブストラクト（33巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Jaw Induction in Vitro from Undifferentiated Presumptive Ectodermal Cells in Vertebrates
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Current Topics of Tissue Engineering in Dentistry
Authors　： Miho Furue
Authors（kana）　：
Organization　： Department of Biochemistry and Molecular Biology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 33
Number　： 1
Page　： 37-42
Year/Month　： 2005 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] To develop an application method for maxillofacial regeneration therapy, it is necessary to understand the mechanisms of maxillofacial development. The blastocoelic roof (animal cap) of Xenopus eggs at the blastula stage shows pluripotency up to the early gastrula stage. Without the inducing factor, the animal caps develop into atypical epidermis. Activin A, a member of the TGF-β family is a potent mesoderm-inducing factor that can induce almost all types of mesodermal and endodermal tissues in animal caps. Using activin A and undifferentiated animal caps, it was presumed that it would be theoretically possible to reproduce embryonic induction. To realize maxillofacial regeneration, my collaborators and I investigated the in vitro induction of jaw from Xenopus undifferentiated animal cap cells using a sandwiched culture method and activin A. This review summarizes the planning and induction of maxillofacial structures from Xenopus undifferentiated animal cap cells in vitro.
Practice　： Dentistry
Keywords　： Jaw, Maxillofacial, Animal cap, Activin A