アブストラクト（33巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Improvement effect of bisphosphonate and VK2 on the bone trabecular structure in overiectomized mice.
Subtitle　： Selective Proceedings of 39th General Meeting of Kanagawa Odontological Society, 2004
Authors　： Yukiko Matsumoto, Hiromi Wakao, Isamu Kashima
Authors（kana）　：
Organization　： Department of Radiology, Kanagawa Dentental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 33
Number　： 2
Page　： 118-120
Year/Month　： 2005 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] We examine the effects of a combined administration of bisphosphonate and vitamin K2 (MK4) on the femur trabecular structure in overiectomized (OVX) mice. We used 9 weeks old female ICR mice. The mice were divided into five groups. We administrated drugs during 2 months. For assessment of the bone trabecular structure, the extracted femur were analysed three-dimensionally by micro-CT with regard to bone structural parameters. As a result, the bone trabecular structure was better preserved in the drug administration than in the OVX-contrel group. But, during in the drug administration groups, the trabecular structure was similar to that. There was no synergistic effect in the trabecular structure due to the combined administration of bisphosphonate and vitamin K2.
Practice　： Dentistry
Keywords　： Osteoporosis, Vitamin K2, Bisphosphonate, Micro CT, Bone trabecular structure