アブストラクト（33巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Experimental osteoporosis by restraining ovariectomized rats
Subtitle　： Selective Proceedings of 39th General Meeting of Kanagawa Odontological Society, 2004
Authors　： Kazuaki Miyagawa1), Yumi Ito3), Hideki Sekiya1),4), Shinji Shimoda5), Toshie Chiba5), Kenzo Kawasaki5), Yuko Mikuni-Takagaki1)
Authors（kana）　：
Organization　： 1)Department of Functional Biology, Kanagawa Dental College, 2)Department of Maxillofacial Diagnostic science, Kanagawa Dental College, 3)Yokohama Training Center, Kanagawa Dental College, 4)First Department of Oral Surgery, Tsurumi University, 5)First Department of Anatomy, Tsurumi University
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 33
Number　： 2
Page　： 121-123
Year/Month　： 2005 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Both the lack of estrogen after menopause and reduced activity (hypokinesis) are the important factors of pathogenesis of osteoporosis in the elderly women. In order to develop an animal model, which allow us to compare the independent contribution of estrogen and activity quantitatively, we kept ovariectomized (OVX) and sham-operated rats either in small cages or in institutional regular cages. The experimental cages restricted them from standing and walking while allowing other activities. Thirty-two Wistar rats, 12 weeks of age, were assigned to four groups of an ambulant Sham-Control, Sham-Restrained, OVX, and OVX-Restrained rats. Animals were sacrificed 7 weeks later. In odd weeks, serum and urine samples were collected to study metabolic bone markers. After sacrificing rats, femora and sacra were examined for the histopathological and morphological appreciation. OVX-Restrained rat group experienced the worst loss of bone structure and bone volume (BV / TV). Highest levels of metabolic makers (osteocalcin and TRAP) were recorded in this group. Osteoclast numbers, however, were not necessarily associated with the osteoporotic pathology, suggesting involvement of another factor yet to be discovered.
Practice　： Dentistry
Keywords　： osteoporosis, ovariectomy, immobilization, bone formation, bone resorption