アブストラクト（33巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Cell proliferation in the dentate gyrus of rat hippocampus is affected by differential diet feeding
Subtitle　： Selective Proceedings of 39th General Meeting of Kanagawa Odontological Society, 2004
Authors　： Hiromichi Aoki, Katsuhiko Kimoto, Norio Hori, Sachio Kushida, Minoru Toyoda
Authors（kana）　：
Organization　： Department of Oral & Maxillofacial Rehabititation, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 33
Number　： 2
Page　： 127-129
Year/Month　： 2005 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] We examined whether cell proliferation varies by chewing tasks with different food textures in the dentate gyrus of the rat hippocampus. Wistar rats were divided into two groups, one fed a solid diet, known as the hard-diet feeding group, and the soft-diet feeding group, which was fed a powder diet containing the same components as the solid one for 3, 7, 16 and 24 weeks. Thymidine analog 5-bromo-2' deoxuridine (BrdU) was used as a marker of cell proliferation within the dentate gyrus of the hippocampus and olfactory bulb. The results of this study indicated that the total number of BrdU-positive cells in the hippocampal dentate gyrus were significantly fewer in the soft-diet feeding group than in hard-diet feeding group in 7, 16 and 24 week old rats after the BrdU injection. The change of BrdU-positive cell expression between soft and hard diets in 24 week old rats was not observed in the olfactory bulb. It has been suggested that cell proliferation in the dentate gyrus of the rat hippocampus is characteristically suppressed by soft diet feeding.
Practice　： Dentistry
Keywords　： Thymidine analog 5-bromo-2' deoxuridine (BrdU), Hippocampus, Soft diet feeding, Chewing task