アブストラクト（34巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Molecular Mechanisms of Periodontium Development ; An Analysis of Cementogenesis based on the Cementum Specific Marker
Subtitle　： SYMPOSIUM ON 40TH CONFERENCE OF KANAGAWA DENTAL COLLEGE Present and Near-future of Regenerative Medicine in Dentistry
Authors　： Masahiro Saito
Authors（kana）　：
Organization　： Department of Operative Dentistry and Endodontics, Kanagawa Dental College, Oral Health Science Research Center, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 34
Number　： 1
Page　： 77-78
Year/Month　： 2006 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The dental follicle is the mesenchymal tissue surrounding the developing tooth germ. During tooth root development, progenitor cells present in the dental follicle are believed to play a central role in the formation of periodontal components (cementum, periodontal ligament [PDL] and alveolar bone). However, little more is known about the biology of these progenitors. To isolate dental follicle progenitors, dental follicle cells were isolated from developing tooth germ, and their life span extended by immortalization. We found that differentiation of immortalized dental follicle cells was induced upon implantation into immunodeficiency mice. After implantation, they formed a cementum-like tissue that is positive for anti-cementum monoclonal antibody, and PDL-like tissue with a strong expression of periostin. Our findings suggested that progenitors for cementoblast and PDL might be able to isolate from immortalized dental follicle cells, and that those cells would provide useful information for investigating the developmental mechanisms of the periodontium.
Practice　： Dentistry
Keywords　：