アブストラクト（34巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Effects of Recombinant Human Bone Morphogenetic Protein-2 and Enamel Matrix Derivative on the Regeneration of Periodontal Tissues
Subtitle　： SYMPOSIUM ON 40TH CONFERENCE OF KANAGAWA DENTAL COLLEGE Present and Near-future of Regenerative Medicine in Dentistry
Authors　： Atsuhiro Kinoshita
Authors（kana）　：
Organization　： Section of Preventive Oral Health Care Science, Department of Oral Health Care Promotion, School of Oral Health Care Sciences, Faculty of Dentistry, Tokyo Medical and Dental University
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 34
Number　： 1
Page　： 85-87
Year/Month　： 2006 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Various studies have reported the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the regeneration of periodontal tissues. Enamel matrix derivative (EMD) has also been applied for the regeneration of periodontal tissue in clinical cases. Although some studies showed significantly enhanced cementum formation on rhBMP-2 application, others did not. Slight ankylosis was also reported in most of the studies. The mechanism by which rhBMP-2 enhances cementum formation is not clear. This paper introduces overviews of two studies regarding periodontal tissue regeneration using rhBMP-2 and EMD in circumstances where there is inhibition of periodontal ligament tissue. The results from the first study indicate that rhBMP-2 (0.4mg/ml) does not induce any new cementum when the coronal migration of cells from intact periodontal ligament tissue is inhibited. The results from the second study indicate that the EMD application seems to enhance connective tissue attachment.
Practice　： Dentistry
Keywords　： Bone morphogenetic protein, Enamel matrix derivative, Periodontal disease, Periodontal regeneration, Tissue engineering