アブストラクト(34巻2号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Immobilization Stress Induces BDNF in Rat Submandibular Gland
Subtitle : Selective Proceedings of 40th General Meeting of Kanagawa Odontological Society, 2005
Authors : Taeki Lee1, Keiichi Tsukinoki2, Juri Saruta1, Kenich Sasaguri1, Sadao Sato1, Yoshihisa Watanabe2
Authors(kana) :
Organization : 1Craniofacial Growth and Development Dentistry, 2Division of Pathology, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 34
Number : 2
Page : 124-126
Year/Month : 2006 / 9
Article : Report
Publisher : Kanagawa Odontological Society
Abstract : Brain-derived neurotrophic factor (BDNF) promotes survival and differentiotion of the central and peripheral nervous system. BDNF has been identified in non-neural tissue, including heart, lung, platelets, lymphocytes BDNF mRNA expression in some organs. The present study examines the effect of immobilization stress on BDNF, and its receptor TrkB, in male rat submandibular glands. Increased BDNF mRNA and protein expression were observed in duct cells as a result of immobilization stress, as demonstrated by real-time PCR, western blot, immunohistochemistry, and analysis by microdissection. TrkB mRNA was not detected in salivary gland tissue, or oral or esophageal mucosa, by RT-PCR. Rat submandibular gland was thus identified as an organ which expresses BDNF. Furthermore, the results of this study suggest that increased salivary BDNF expression occurs following immobilization stress
Practice : Dentistry
Keywords : BDNF, TRKB, Stress, Salivary gland