アブストラクト（35巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： The effect of vitamin K2 and risedronate on the properties of osteoporotic mouse femur depends on the sequence of administration.
Subtitle　： Selective Proceedings of 41st General Meeting of Kanagawa Odontological Society, 2006
Authors　： Yukiko Matsumoto1), Yuko Mikuni-Takagaki2), Kazuaki Miyagawa2), Hiromi Wakao1), Yusuke Kozai1), Ryota Kawamata1), Takashi sakurai1), Koji Nakamura1), Isamu Kashima1)
Authors（kana）　：
Organization　： 1)Division of Radiology, Department of oral and maxillofacial diagnostic sciences, Kanagawa Dental College, 2)Department of Functional biology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 35
Number　： 2
Page　： 196-199
Year/Month　： 2007 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT]The objective of this study is to determine the effects of different type of combined administration with vitamin K2 (MK4) and bisphosphonate (risedronate) on the bone mineral density, trabecular bone structure, and bone strength. 37, nine week-old female ICR mice were used for this experiment. After they were kept with regular feed for 30 days, the test mice were divided into five groups, based on the administration methods of risedronate(R) and MK4(K) as follows: 1) sham 2) OVX-control (control), 3) concomitant administration of R and K (2RK), 4) administration of K after R (R→K), 5) administration of R after K (K→R). After 16-week observation period, the left femur of each mouse was removed and subjected to analysis of bone mineral density, bone structure by bone peripheral quantitative computed tomography (pQCT) and micro focus x-ray CT (μCT). In the pQCT examination, the total bone mineral density in K→R group showed significantly higher values than the control group. The μCT analysis revealed that the trabecular bone structure in K→R group displayed a significant improvement, compared with the control group. In the mechanical test for bone strength, only K→R group showed a significantly higher improvement in comparison to the OVX-control group. It was suggested that sequential administration of vitamin K2 and risedronate was superior to other types of combined administration for treating osteoporosis.
Practice　： Dentistry
Keywords　： osteoporosis, vitamin K2, risedronate, combined therapy