アブストラクト（35巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Osteocyte Functions and Bone Metabolism in MMP-2 Knockout Mouse
Subtitle　： Selective Proceedings of 41st General Meeting of Kanagawa Odontological Society, 2006
Authors　： Yuko Mikuni-Takagaki1), Keiichi Inoue2),3),4), Kaoru Oikawa3), Takeshi Itoh5), Takanori Noguchi2), Jin-Sung Park2),4), Masaki Noda3), Shigeyoshi Itohara2)
Authors（kana）　：
Organization　： 1)Department of Functional Biology, Kanagawa Dental College, 2)Laboratory for Behavioral Genetics, RIKEN BSI, 3)Department of Molecular Pharmacology, Medical Reserch Institute, and Center of Excellence Program for Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical & Dental University, 4)Department of Molecular Immunology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 5)Discovery Research Laboratories, Shionogi & Co.,Ltd.
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 35
Number　： 2
Page　： 200-203
Year/Month　： 2007 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract]Mmp2-/- mice, lacking a matrix (ECM) degrading enzyme MMP-2, showed decreased bone mineral density in limb and trunk bones, but increased bone volume in calvariae. In the long bones, there was moderate disruption of the osteocytic networks and reduced bone density throughout life, while osteoblast and osteoclast function was normal, in contrast, aged but not young Mmp2-/- mice had calvarial sclerosis with cell death of osteocytes, Severe disruption of osteocytic networks preceded osteocyte loss in Mmp2-/- calvariae. Local roles of MMP-2 expressed by the bone cells seem to be critical in bone metabolism.. Our results indicate that MMP-2 plays a crucial role in formation and maintenance of the osteocytic canalicular network, which controls remodeling and mineralization in reflection of their mechanical environment.
Practice　： Dentistry
Keywords　： MMP-2, osteocyte, mineralization, bone, abnormality