アブストラクト（35巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： The inhibitory effects of COX-2 inhibitor, alendronate and β-blocker on alveolar bone loss in rats
Subtitle　： Selective Proceedings of 41st General Meeting of Kanagawa Odontological Society, 2006
Authors　： Yul Kim1), Nobushiro Hamada2), Kenichi Sasaguri1), Sadao Sato1)
Authors（kana）　：
Organization　： 1)Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College, 2)Department of Infection Control, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 35
Number　： 2
Page　： 213-215
Year/Month　： 2007 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT]Adult periodontitis is initiated by a primary pathogen such as Porphyromonas gingivalis. The presence of restrain stress showed a significant augmentation on P. gingivalis-challenged periodontitis in rats. We investigated the inhibitory effects of COX-2 inhibitor, alendronate and β-blocker on alveolar bone loss challenged by P. gingivalis and restraint stress in rats. In the groups treated with COX-2 inhibitor, alendronate and β-blocker, the increasing rate of body weight was decreased and the thymus and spleen were atrophied. The groups treated with COX-2 inhibitor, alendronate and β-blocker showed the remarkable inhibition in augmented alveolar bone loss challenged by P. gingivalis. It can be thought that COX-2 inhibitor is more effective in reducing alveolar bone loss because it seems to have less systemic influence and more inhibitory effect than the other drugs. Therefore, COX-2 inhibitor plays a crucial role in the pathogenesis of periodontitis, as systemic treatment prevented alveolar bone loss challenged by P. gingivalis.
Practice　： Dentistry
Keywords　： Alveolar bone loss, Porphyromonas gingivalis, COX-2 inhibitor, Alendronate, β-blocker