アブストラクト（36巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Influence of Diabetes on Mandibular Trabecular Structure - Evaluation in a Rat Model of Spontaneous Type 2 Diabetes -
Subtitle　： Selective Proceedings of 42nd General Meeting of Kanagawa Odontological Society, 2007
Authors　： Ryota Kawamata, Yuka Nakamura, Yusuke Kozai, Takashi Sakurai, Isamu Kashima
Authors（kana）　：
Organization　： Division of Radiology, Department of oral and maxillofacial diagnostic sciences, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 36
Number　： 2
Page　： 81-83
Year/Month　： 2008 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] Objective : To investigate the influence of diabetes on trabecular structure of the mandible in a spontaneous animal model of diabetes mellitus. Methods : Glucose tolerance testing and monitoring of urine glucose was performed from 8 weeks to 81 weeks of age in Goto-Kakizaki diabetic rats (DM group : n=10) and Wistar rats (control group : n=9). Mandibular molar bone was resected and evaluated by pQCT to analyze bone mineral density (BMD), cross-sectional morphology, and the bone strength index. Micro CT was also performed to evaluate the 3-dimensional structure of bone from the same site, including the alveolar crest level, morphometric indices, connectivity index, and continuity index. Results : The alveolar crest level did not significantly differ between the DM and control groups. As compared to the control group, the trabecular BMD was significantly decreased in the DM group, but there was no significant difference in cortical BMD. However, parameters of morphological changes and the SSI, an index of bone strength, were significantly decreased in the DM group vs. the control group. Morphometric indices, the connectivity index, and the continuity index showed a coarser trabecular structure in the DM group vs. the control group. Conclusion : Diabetes has a significant effect on mandibular trabecular structure and may lead to a deterioration in bone quality.
Practice　： Dentistry
Keywords　： diabetes, bone structure, mandible, bone morphometry