アブストラクト(36巻2号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Chemokine BRAK Stimulates Apoptosis of Oral Squamous Cell Carcinoma Caused by Gefitinib
Subtitle : Selective Proceedings of 42nd General Meeting of Kanagawa Odontological Society, 2007
Authors : Shin Ito1),2), Shigeyuki Ozawa1),2),3), Naoto Shiiki4), Keiichi Tsukinoki1),4), Eiro Kubota1),3), Yasumasa Kato1),2),5), Takahide Taguchi5), Yukari Imagawa-Ishiguro5), Mamoru Tsukuda5), Ryu-Ichiro Hata1),2)
Authors(kana) :
Organization : 1)Oral Health Science Research Center, 2)Department of Biochemistry and Molecular Biology, Kanagawa Dental College, 3)Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 4)Department of Pathology, Kanagawa Dental College, 5)Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine
Journal : The Bulletin of Kanagawa Dental College
Volume : 36
Number : 2
Page : 87-89
Year/Month : 2008 / 9
Article : Report
Publisher : Kanagawa Odontological Society
Abstract : [ABSTRACT] The chernokine BRAK/CXCL 14 is expressed in many normal cells, but absent or expressed at very low levels in transformed cells and cancerous tissues including oral carcinoma. We reported previously that BRAK had suppressive activity toward tumor progression of oral carcinoma in vivo when over-expressed in tumor cells. Oral administration of gefitinib (Iressa, ZD 1839), an anti-tumor drug developed for molecular targeting therapy for the epidermal growth factor receptor, significantly reduced tumor volumes with a restorative increase in BRAK mRNA expression. In order to investigate the mechanisms of the tumor suppression in vivo, we xenografted nude mice with HSC-3 cells that had been transfected with corltrol Si-scrambled vector or siRNA of BRAK to down-regulate the BRAK mRNA expression. Oral administration of gefitinib inhibited the proliferation of the tumor cells transfected with either Si-scrambled or Si-BRAK vector. But the increase in apoptosis initiated by gefitinib was significantly reduced in the case of tumor cells transfected with Si-BRAK. These results suggest that BRAK stimulates apoptosis initiated by gefitinib.
Practice : Dentistry
Keywords : BRAK, CXCL 14, chemokine, gefitinib, epidermal growth factor receptor