アブストラクト(36巻2号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Determination of Transcriptional Start Site and Promoter Sequence of BRAK/CXCL 14 Gene
Subtitle : Selective Proceedings of 42nd General Meeting of Kanagawa Odontological Society, 2007
Authors : Reika Komori1),4), Shigeyuki Ozawa1),2),3), Yasumasa Kato1),2), Hisaaki Shinji4), Shigenari Kimoto4), Ryu-Ichiro Hata1),2)
Authors(kana) :
Organization : 1)Oral Health Science Research Center, 2)Department of Biochemistry and Molecular Biology, Kanagawa Dental College, 3)Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 4)Department of Pediatric Dentistry, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 36
Number : 2
Page : 90-92
Year/Month : 2008 / 9
Article : Report
Publisher : Kanagawa Odontological Society
Abstract : [ABSTRACT] BRAK/CXCL 14 is a chemokine, which was first reported to be expressed in breast and kidney tissues but later was found in many other normal cells and tissues but absent or expressed at very low levels in transformed cells and cancerous tissues including oral carcinoma. We previously reported that BRAK/CXCL 14 to have suppressive activity toward tumor progression of oral carcinoma in vivo. It is thought that there is an inverse relationship between tumor progression and expression levels of BRAK/CXCL 14. Thus, in order to study the regulatory mechanisms of this gene, we determined the transcriptional start site and promoter sequence of the gene. The transcriptional start site was found to be in the previously reported exon 1 region of the gene ; and TATA-like sequence was essential for the transcription of the gene. Also the AP-1 binding sequence was necessary for stimulating the expression of the gene.
Practice : Dentistry
Keywords : BRAK/CXCL 14, Transcription start site, Promoter, Enhancer