アブストラクト（36巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) in Synovial Fluid of Temporomandibular Disease Patients
Subtitle　： Selective Proceedings of 42nd General Meeting of Kanagawa Odontological Society, 2007
Authors　： Yoshiaki Kawai1), Daitarou Tajima1), Fumihiko Yoshino2), Shun-suke Takahashi2), Masaichi(Chang-il)Lee2), Eiro Kubota1)
Authors（kana）　：
Organization　： 1)Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 2)Department of Pharmacology and ESR Laboratory, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 36
Number　： 2
Page　： 93-96
Year/Month　： 2008 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] In the present study, we evaluated the reactive oxygen species (ROS) such as hydroxyl radical (HO') and reactive nitrogen species (RNS) such as nitric oxide (NO') in synovial fluid (SF) of the temporomandibular joint (TMJ). This study comprised 9 patients (9 joints) with temporomandibular disease (TMD) and from 5 asymptomatic healthy volunteers (5 joints) as control. Visual analog scale, tenderness of TMJ, and pain at mandibular movements were registered, and the pressure pain threshold was measured. The characterization of HO' with NO' in SF were analyzed using by X-band electron spin resonance (ESR) spectroscopy and NO' selective electrode. It was shown that significant correlation was observed in tenderness of TMJ and HO' generation. We also confirmed that no significant difference of both HO' and NO' generation between TMD patients and control. Interestingly, the results in this study demonstrated revered correlation between HO' generation and NO' generation in SF of TMD patients. These results suggested that redox reaction in SF of TMJ, including the balance of both ROS and RNS generation, may be involved in the pathogenesis of TMD.
Practice　： Dentistry
Keywords　： temporomandibular disesase, synovial fluid, reactive oxygen species, reactive nitrogen species, Electron spin resonance