アブストラクト（37巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Detection of Salivary Peroxidase Specific mRNA Expression in Healthy Parotid Glands by in situ Hybridization
Subtitle　： ORIGINAL ARTICLES
Authors　： Jun Onozaki*1, Keiichi Tsukinoki*2, Juri Saruta*3, Sadao Sato*3, Jerry R.McGhee*4, Hiroshi Kiyono*4, Kohtaro Fujihashi*4, Firoz Rahemtulla*5
Authors（kana）　：
Organization　： *1Division of Orthodontics, Department of Comprehensive Dentistry, Yokohama Dental and Medical Clinic, Kanagawa Dental College, *2Division of Pathology, Department of Diagnostic Science, Kanagawa Dental College, *3Division of Orthodontics, Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College, *4Mucosal Immunization Research Group, Immunobiology Vaccine Center, Departments of Microbiology and Oral Biology, University of Alabama at Birmingham Medical Center, *5Departments of Prosthodontics and Biomaterials, School of Dentistry, The University of Alabama at Birmingham
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 37
Number　： 2
Page　： 89-93
Year/Month　： 2009 / 9
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] It is known that there are four kinds of active oxygen species (AOS) for superoxide, hydroxyl radical, hydrogen peroxide and singlet oxygen. Mammalian cells have several protective mechanisms to remove these AOS. The salivary glands are a unique organ in that they have an additional protective mechanism to remove these AOS, namely, the salivary peroxidase (SPO) system. There have been few reports on the expression of SPO-specific mRNA in healthy parotid glands. In this study we investigated the expression of SPO-specific mRNA in healthy parotid glands in using in situ hybridization. Extant studies using in situ hybridization techniques demonstrate that in healthy parotid glands the intense expression of SPO mRNA is localized in the centroacinal cells and intercalated duct cells.
Practice　： Dentistry
Keywords　： Salivary peroxidase, Parotid gland, Hydrogen peroxide, Acinar cells, Thiocyanate