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アブストラクト（38巻1号：The Bulletin of Kanagawa Dental College）
English
| Title ： | The Role of Brain - Derived Neurotrophic Factor (BDNF) in Stress |
|---|---|
| Subtitle ： | BKDC CLINICAL AND RESEARCH TOPICS |
| Authors ： | Juri Saruta |
| Authors（kana） ： | |
| Organization ： | Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College |
| Journal ： | The Bulletin of Kanagawa Dental College |
| Volume ： | 38 |
| Number ： | 1 |
| Page ： | 37-41 |
| Year/Month ： | 2010 / 3 |
| Article ： | Report |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract] Brain-derived neurotrophic factor (BDNF) promotes survival and differentiation of the cells of the central and peripheral nervous systems. BDNF has been identified in non-neural tissue, including the heart, lung, platelets, lymphocytes, and lacrimal glands. Immobilization stress modifies BDNF mRNA expression in some organs. The present study examines the effect of immobilization stress on BDNF, and its receptor TrkB, in male rat submandibular glands. Increased BDNF mRNA and protein expression were observed in duct cells as a result of immobilization stress, as demonstrated by real-time PCR, Western blot, immunohistochemistry, and analysis by microdissection. TrkB mRNA was not detected in salivary gland tissue, oral or esophageal mucosa, by RT-PCR. The rat submandibular gland was thus identified as an organ that expresses BDNF. Furthermore, the results of these studies suggest that increased salivary BDNF expression occurs following immobilization stress. |
| Practice ： | Dentistry |
| Keywords ： | Brain-derived neurotrophic factor, Saliva, Salivary gland, Stress |
