アブストラクト(38巻1号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Type III Collagen Mediates Ascorbic Acid 2-Phosphate Dependent Cell Proliferation of Human Osteoblasts
Subtitle : BKDC CLINICAL AND RESEARCH TOPICS
Authors : Yojiro Maehata1),2)
Authors(kana) :
Organization : 1)Department of Clinical Care Medicine, Division of Pharmacology, Kanagawa Dental College, 2)Oral Health Science Research Center, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 38
Number : 1
Page : 45-47
Year/Month : 2010 / 3
Article : Report
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] It has been reported that the collagen molecule is required for cell proliferation and differentiation in cells, including human osteoblastic cells. It was also indicated that ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative regulates the proliferation and differentiation of human osteoblastic cells. Nevertheless, the types of collagen responsible for regulation of cell growth and differentiation of the cells are not known. In order to investigate the functions of the respective collagen components on the growth and differentiation of osteoblasts, we used human osteoblast-like cells and normal human osteoblasts, as well as human bone marrow derived mesenchymal stem cells. We cultured them in the presence or absence of Asc 2-P, and examined the relationship between specific collagen types and the growth of the cells. Stimulation of cell proliferation by the addition of Asc 2-P is closely associated with an increase in the synthesis of type III collagen. Inhibition of type III collagen synthesis by adding the respective siRNAs was observed to attenuate the effects of those agents on the proliferation of the cells. These results suggest that type III collagen regulates the growth of human osteoblastic cells. This review describes the function of type III collagens as a regulatory molecule for the proliferation and differentiation of human osteoblastic cells and discusses the possibility that collagen metabolism is a possible new target for the treatment of osteoporosis.
Practice : Dentistry
Keywords : Osteoblast, Type III Collagen, Ascorbic acid 2-Phosphate