アブストラクト（38巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Expression of Toll-like Receptor 2 and 4 in the Inflamed Pulp of BALB / C and Severe Combined Immunodeficient Mice
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS
Authors　： Noriko Mutoh
Authors（kana）　：
Organization　： Division of Endodontics, Department of Oral Medicine, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 38
Number　： 1
Page　： 53-54
Year/Month　： 2010 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The defense system in dental pulp is based on both innate and adaptive immune mechanisms as in other tissue. Pulp tissue contains numerous MHC class II-positive cells, most of which effectively present antigens to initiate the immune response to oral microorganisms. These cells are distributed throughout the pulp tissue and some are dendritic cells (DCs) that are localized between the odontoblast layer and the professional antigen presenting cells for the helper T cells. DCs are derived from bone marrow and migrate as immature DCs toward the front line of defense. Immature DCs express various pattern-recognition receptors such as Toll-like receptors (TLRs) for capturing and endocytosing foreign antigens. Toll-like receptors play a role in innate immunity and recognize and respond to different microbial components. Signal activation through TLRs induces a release of various cytokines and mediators for immune responses by regulating endocytosis and triggering antimicrobial activity. However, very little data is available on the role of TLRs in the dental pulp. The current study aims to investigate the relationship between the innate immune system and the defense mechanism of pulp tissue using both wild-type (WT) mice(BALB/C) and severe combined immunodeficient (SCID) mice.
Practice　： Dentistry
Keywords　：