アブストラクト（38巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Detection of Amyloid p protein in the hippocampus and the plasma of Alzheimer's disease-model molarless-mice
Subtitle　： Selective Proceedings of 44th General Meeting of Kanagawa Odontological Society, 2009
Authors　： Masatsuna Kawahata1), Akinori Ohnn1), Yojiro Maehana2), Masaichi-Chang-il Lee2), Katsuhiko Kimoto1)
Authors（kana）　：
Organization　： 1)Division of Fixed Prostodontics, Dept of Oral & Maxillofacial Rehabilitation, 2)Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 38
Number　： 2
Page　： 88-90
Year/Month　： 2010 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] We examined whether the amount of Aβ protein detected With the hippocampus and the plasma of the molarless senescence prone (SAMP8) mice, to study correlation between the amount of Aβ protein in the hippocampus and in the plasma. We extracted all upper molar teeth of 8-week-old male SAMP8 mice (n=16). We measured the amount of Aβprotein in the hippocampus and the plasma of SAMP8 molarless-mice either at 24 weeks (n=9) or 48 weeks (n=7) of age using commercial ELISA (Enzyme-Linked Immunosorbent Assay) kit. Our results clearly show that quantitative detection of Aβ protein is available both from the hippocampus and the plasma of the SAMP8 mice, and that the mean amount of Aβ protein in the hippocampus and the plasma were significantly larger in the molarless SAMP8 mice at 48 weeks of age than those at 24 weeks of age. It would be likely that the amount of Aβ protein in the hippocampus tended to correlate with that in the plasma of SAMP8 molarless-mice.
Practice　： Dentistry
Keywords　： Alzheimer's disease, SAMP8, Aβ protein, ELISA, hippocampus