アブストラクト（39巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Occlusal Adjustment Reduces Oxidative Stress in Rat Brain
Subtitle　： ORIGINAL ARTICLES
Authors　： Tatsunori Ikeda*1, Fumihiko Yoshino*2, Kyo Kobayashi*2, Ayaka Yoshida*2, Shuta Sugiyama*2, Katsushi Tamaki*1, Katsuhiko Kimoto*3, Minoru Toyoda*1, Masaichi-Chang-il Lee*2
Authors（kana）　：
Organization　： *1Division of Removal Prosthetics, Department of Oral and Maxillofacial Rehabilitation, Kanagawa Dental College, *2Division of Pharmacology & ESR Laboratories, Department of Clinical Care Medicine, Kanagawa Dental College, *3Division of Fixed Prosthodontics, Department of Oral and Maxillofacial Rehabilitation, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 39
Number　： 1
Page　： 11-17
Year/Month　： 2011 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The authors investigated oxidative stress in rat brain, which brought about occlusal interference, for the purpose of examining the influence that change of occlusion had on that organ. The experiments were conducted over a period of four weeks. Three groups of laboratory animals were compared; an occlusal interference group, which had an occlusal interference device attached to the molar for four weeks, an occlusal adjustment group in which the occlusal interference device was removed after two weeks, and a control group. In each group, after the end of the period of the experiment, measurements were taken of cerebral blood flow and L-band electron spin resonance, which use a blood-brain barrier permeable nitroxyl spin probe, 3-methoxycarbonyl-2,2,5,5,-tetramethylpyrrolidine-1-oxyl in the isolated brain. No difference was observed in the cerebral blood flow in each group, but L-band electron spin resonance revealed that the decay rate of 3-methoxycarbonyl-2,2,5,5,-tetramethylpyrrolidine-1-oxyl in the isolated brain after occlusal interference was more rapid than that in the control group, suggesting that occlusal interference is associated with increased oxidative stress. It is interesting to note that occlusal adjustment caused the decay rate constant of 3-methoxycarbonyl-2,2,5,5,-tetramethylpyrrolidine-1-oxyl in isolated brain to approach that of the control group. These observations suggest that occlusal interference may be suppressed by prior oxidative stress and occlusal adjustment. They also suggest that anti-stress masticatory motor activity movement, such as occlusal adjustment, plays an important role in alleviating the adverse effects associated with occlusal interference. In addition, the results indicate that the L-band electron spin resonance technique employed herein can be a powerful tool to evaluate oxidative stress and other associated physiological stress that may occur during prosthodontic dentistry.
Practice　： Dentistry
Keywords　： Oxidative stress, Brain, Occlusal adjustment, Occlusal interference, Electron spin resonance