アブストラクト(39巻1号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Review: Titanium Dioxide (TiO2) Photocatalysis and Reactive Oxygen Species (ROS)
Subtitle : BKDC CLINICAL AND RESEARCH TOPICS: New Technology: TiO2 Photocatalyst and Dental Materials Basic Research
Authors : Masaichi Chang-il Lee
Authors(kana) :
Organization : Division of Pharmacology & ESR Laboratories, Department of Clinical Care Medicine, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 39
Number : 1
Page : 25-27
Year/Month : 2011 / 3
Article : Report
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] Titanium dioxide (TiO2) is well known as a photocatalyst that can be utilized semi-permanently as an environment purification material. TiO2 decomposes harmful chemical materials and reactive oxygen species (ROS) in microorganisms such as hydroxyl radicals (HO・) and superoxide (O2・-). This review focuses on laboratory results using in vivo ESR spin trapping techniques that may serve as a useful basis for measuring ROS in dental materials, including those with a TiO2 photocatalyst. We demonstrated this in TiO2, both with and without apatite coating, with H2O2 generated ROS such as HO・ and O2・- using DMPO as an ESR spin trap. It may well be possible to harness the antifungal and oxidant effects resulting from the ability of acrylic resin or bleaching reagents containing apatite-TiO2 to generate ROS via photocatalysis to develop a wide range of materials that will facilitate dental treatment. Furthermore, ESR will prove to be a powerful technique to detect and monitor ROS from TiO2 photocatalysts in dental treatment. Titanium dioxide (TiO2) is well known as a photocatalyst that can be utilized semi-permanently as an environment purification material. It is possible that reactive oxygen species (ROS) such as hydroxyl radicals (HO・), superoxide (O2・-), and hydrogen peroxide (H2O2) are involved in the photocatalysis of TiO2. During the process of inflammation, ROS generation plays an important role in the antimicrobial action of polymorphonuclear leukocytes. TiO2 decomposes harmful chemical materials and microorganisms involving HO・. Several investigators have reported on the use of TiO2 in dental materials, including tooth bleaching, as a dentifrice, and as a tissue conditioner in dental treatment. This review will concentrate on the hypothesis that ROS performs a major role in the antimicrobial effects of dental materials, including the TiO2 photocatalyst. Thus, we demonstrate that results from our laboratory using in vivo ESR spin trapping techniques could serve as a useful basis for measuring ROS in dental materials, including the TiO2 photocatalyst. We evaluated the characterization of ROS in dental materials, including the TiO2 photocatalyst, using ESR.
Practice : Dentistry
Keywords : Titanium dioxide (TiO2), Photocatalysis, Reactive oxygen species (ROS), Electron spin resonance (ESR)