アブストラクト(39巻2号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Brain-Derived Neurotrophic Factor (BDNF) Administration Suppresses Stress-related Lesions
Subtitle : ORIGINAL ARTICLES
Authors : Takahiro Nagasawa*1, Juri Saruta*1, Yusuke Kondo*1, Masahiro To*1, Youhei Kamata*2, Mayumi Hori*1, Fumihiko Yoshino*3, Takashi Maetani*3, Masaichi Chang-il Lee*3, Keiichi Tsukinoki*1
Authors(kana) :
Organization : *1Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College, *2Department of Comprehensive Dentistry, Kanagawa Dental College, *3Department of Clinical Care Medicine, Division of Pharmacology, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 39
Number : 2
Page : 79-82
Year/Month : 2011 / 9
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of cells in the central and peripheral nervous systems and protects gastrointestinal organs from stress. The purpose of this study was to determine whether BDNF is capable of rescuing stress disorders in BDNF conditional knock-out mice (BDNF KO mice). Nine-week-old male mice, strain STOCK Bdnftm3Jae/J were used in this study. These animals were stressed by immobilization up to the neck in water for three or six hours. Recombinant BDNF (1μg) was injected into the tail vein one hour before stress application. The stomach damage in these mice was compared with non-injected, stressed and non-stressed mice. Liver damage was also assessed by analysis of the GOT and GPT sera. In contrast to non-injected stressed mice, no bleeding of the gastric mucosa was observed in BDNF KO mice that had been injected with recombinant BDNF prior to stress. Injection of recombinant BDNF showed a tendency to relieve stress-induced liver damage. However, the decrease in liver damage was not significant compared to that of the control groups. In this KO mouse, recombinant BDNF may suppress bleeding from gastric mucosal lesions under stress and this effect may be mediated via the hypothalamus-regulated sympathetic nerve.
Practice : Dentistry
Keywords : BDNF, gastric mucosal lesion, liver, GOT, GPT, KO mice