アブストラクト（39巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Global trend toward standardization: The discovery of titanium-aging and revolutionary implant treatment with photo-functionalized technology
Subtitle　： Selective Proceedings of 45th General Meeting of Kanagawa Odontological Society, 2010
Authors　： Norio Hori, Akinori Ohno, Atsushi Kuwabara, Katsuhiko Kimoto
Authors（kana）　：
Organization　： Division of Fixed Crown bridge, Department of Oral and Maxillofacial Rehabilitation
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 39
Number　： 2
Page　： 111-113
Year/Month　： 2011 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] We have a historical discovery in the implant research. We are finding this "biological aging of titanium" and named. Biological aging is that protein adsorption capacity and cell attractiveness of Ti, which are critical to the process of osseointegration, changes over time before its use. We have verified this phenomenon and tried an overcome aging using photo-functionalized technology. Ti disk with micro-structure topographies was prepared: acid-etched surface. Some disks were tested for biological capacity immediately after the processing and some after being stored under dark ambient conditions for 4 weeks. Furthermore, we examined the bioactivity of ultraviolet (UV) light-treated titanium surface. Protein adsorption capacity of Ti was examined using albumin. Cell attractiveness of titanium was evaluated by examining the number of rat bone marrow-derived osteoblasts attached to Ti disks. Protein adsorption capacities of 4-week-old Ti disks were substantially lower than the fresh Ti disks. After 24h incubation, the number of cells attached to the fresh surface was over three times more than those attached to the 4-week-old surface. On the UV-treated surface, the cellular spread was same as a fresh surface expedited with an extensive. Degrading trend of protein adsorption capacity and osteoblast attractiveness of Ti surfaces during 4 weeks of storage after processing was remarkable. UV light pretreatment substantially enhanced the osseointegration capacity of titanium surface. These results are found to change the definition of material science. We believe that the first step of historical turning point in providing innovative technology of implant treatment.
Practice　： Dentistry
Keywords　： titanium aging, photo-functionalized technology, implant, Protein adsorption, cell attachment