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アブストラクト(39巻2号:The Bulletin of Kanagawa Dental College)
English
Title : | Dental pulp innate immune response contribute to the dentin regeneration |
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Subtitle : | Selective Proceedings of 45th General Meeting of Kanagawa Odontological Society, 2010 |
Authors : | Noriko Mutoh, Nobuyuki Tani-Ishii |
Authors(kana) : | |
Organization : | Division of Endodontics, Department of Oral Medicine, Kanagawa Dental College |
Journal : | The Bulletin of Kanagawa Dental College |
Volume : | 39 |
Number : | 2 |
Page : | 132-134 |
Year/Month : | 2011 / 9 |
Article : | Report |
Publisher : | Kanagawa Odontological Society |
Abstract : | [Abstract] Toll-like receptors (TLRs) are important factors in innate immune responses because they mediate signals from bacterial cell wall components during inflammatory reactions. However, the roles of TLRs in dental pulp, which is bounded by hard tissues, are little understood.The present study investigated TLRs expression cells in inflamed pulp to elucidate the dental pulp tissue regenerative mechanism. Twenty-four female BALB/c mouse were used in this study. Experimental pulpitis was induced by oral microorganism infection. The expression of TLR-2 and TLR-4 in pulpitis was investigated by immunohistochemistry. Experimental teeth were obtained on days 1, 3, 5, 7, 14, and 21 after pulp exposure. TLR-2, TLR-4 and nestin positive cells (odontblast) were investigated with immunohistochemistry. By 1 day after preparation, numerous inflammatory cells (PMNs, macrophage) infiltrated in pulp tissue, andTLR-4 positive cells presented in periapical tissue and alveolar bone marrow until 7 days. The healing response of pulp tissue was observed by the regeneration of the odontoblast layer and TLR-4 positive cells under pulp exposure area on days 21. These results suggested that dental pulp tissue and dentin regeneration to pulp infection relate to the possible role of TLR-4 presenting cells in dental pulp and alveolar bone marrow. |
Practice : | Dentistry |
Keywords : |