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アブストラクト（16巻2号：神奈川歯学）
Japanese
| Title ： | マウスの尿中生体アミンに関する研究 第3報 : 抜歯によるセロトニン, ヒスタミンおよびカテコールアミンの変動について |
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| Subtitle ： | 原著 |
| Authors ： | 秋場仁 |
| Authors（kana） ： | |
| Organization ： | 神奈川歯科大学生化学教室 |
| Journal ： | 神奈川歯学 |
| Volume ： | 16 |
| Number ： | 2 |
| Page ： | 289-300 |
| Year/Month ： | 1981 / 9 |
| Article ： | 原著 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「抄録」 ddYマウスの上顎切歯2歯の抜去が, 尿中ヒスタミン量, 尿中カテコールアミン量, 尿中5-HIAA量, 血中セロトニン量, 体重, 飲水量および尿量におよぼす変化を経日的あるいは経時的に測定した. 血中セロトニン量は抜歯後短時間で高濃度に達し, 64時間にわたって対照値の約10倍の濃度が維持された. この現象は, 尿中5-HIAA量として, 抜歯後3日目から反映された. 尿中ヒスタミン量は, 抜歯後1日目に最高濃度に達した. 尿中カテコールアミンのうち, エピネフリンは抜歯後2日目から5日目にわたって高濃度が維持され, ノルエピネフリンおよびドーパミンはいずれも抜歯後1日目から著明に減少し, 実験期間を通して回復しなかった. PCPAによるセロトニン枯渇実験において, 尿中エピネフリン量が著明に減少した. 以上の結果から, 抜歯侵襲はセロトニンとエピネフリンに密接な関係をもちながら, 体重, 飲水量および尿量に影響することを明らかにした. |
| Practice ： | 歯科学 |
| Keywords ： |
English
| Title ： | The Studies on Biogenic Amines in Urine of mice. 3 : The Changes of Biogenic Amines Induced by Extraction of the Upper Incisors in Mice. |
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| Subtitle ： | |
| Authors ： | Chikashi AKIBA |
| Authors（kana） ： | |
| Organization ： | Department of Biochemistry, Kanagawa Dental College |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 16 |
| Number ： | 2 |
| Page ： | 289-300 |
| Year/Month ： | 1981 / 9 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | The changes of histamine, catecholamines, 5-hydroxy-indolacetic acid in urine and serotonin in blood were investigated in course of elapsed time after the extraction of upper incisors in adult ddY mice, while these of body weight, water consumption and urine volume were also observed. After teeth extraction, serotonin level was immediately increased within 2 hours and the extremely high serotonin level was maintained for 64 hours, but 5-hydroxyindoleacetic acid began to increase in urine on the 3rd day later. Norepinephrine and dopamine in urine were progressively decreased in comparison with sham operated group and yet these changes did not recover to both of the normal value. However, epinephrine was increase contrary on 2 nd day later after teeth extraction. The increase of urinary epinephrine induced by teeth extraction was not only completely disappeared but also extremely decreased in PCPA treated mice. Norepinephrine and dopamine were remarkably decreased in PCPA treated mice, too. Urinary histamine reached the maximum on the next day following teeth extraction and then slightly decreased in proportion as the course of time. The changes of body weight, water consumption and urin volume after teeth extraction were more increased in PCPA treated mice than in non-treated mice. These results suggest that the most reactive biogenic amines induced by teeth extraction is serotonin which may stimulate the release of epinephrine, and the increase of histamine may be considered as a necessary consequence of stress due to extraction. |
| Practice ： | Dentistry |
| Keywords ： |
