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アブストラクト（24巻3号：神奈川歯学）
Japanese
| Title ： | 排泄管導管結紮後のラット顎下腺の再生 |
|---|---|
| Subtitle ： | 原著 |
| Authors ： | 三辺メイ1), 高橋和人2), 久田太郎3) |
| Authors（kana） ： | |
| Organization ： | 1)神奈川歯科大学病理学教室, 2)神奈川歯科大学口腔解剖学教室, 3)湘南短期大学 |
| Journal ： | 神奈川歯学 |
| Volume ： | 24 |
| Number ： | 3 |
| Page ： | 484-500 |
| Year/Month ： | 1989 / 12 |
| Article ： | 原著 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「緒言」唾液腺は, 唾石や機械的侵襲あるいは細菌感染等により唾液の流出が抑制された場合には閉塞性唾液腺炎の病態を呈する. この病態像は, 唾液腺の排泄管結紮を行った動物実験にて多数検索されており, その形態変化として腺組織は小葉内導管の拡張と腺房の萎縮, 消失を伴う著しい荒廃を生じることが観察されている. 一方, 導管閉塞によって荒廃した顎下腺は, 排泄管の再疎通で本来の構造に修復されることが報告されている. Hanksらは, ラット顎下腺の部分切除を行い, 再生過程には再びterminal tubuleが形成され, その構成細胞から腺房細胞が分化することを示唆した. この再生過程にみられるterminal tubuleの構成細胞と同一の細胞型は, 導管結紮後の腺の修復過程でも認められ, 形態変化した腺房細胞ないし増殖した導管上皮であることが推察されている. 従って, 傷害された腺組織における腺房の回復が, 導管上皮の分化により形成されたものか, または残存腺房細胞の発達によるものであるか, 未だ明確な見解は得られていない. |
| Practice ： | 歯科学 |
| Keywords ： | 導管結紮, 結紮解除, Bromodeoxyuridine |
English
| Title ： | Regeneration of the Rat Submandibular Glands after Duct Ligation |
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| Subtitle ： | Original article |
| Authors ： | Mei MINABE1), Kazuto Takahashi2), Taro Hisada3) |
| Authors（kana） ： | |
| Organization ： | 1)Department of Pathology, Kanagawa Dental College, 2)Department of Oral Anatomy, Kanagawa Dental College, 3)Shounan Junior College |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 24 |
| Number ： | 3 |
| Page ： | 484-500 |
| Year/Month ： | 1989 / 12 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | Abstract : The cytomorphologic changes associated with acinar cell recovery in the rat submandibular glands were examined by light and electron microscopic observation and immunohistochemical test using anti-bromodeoxyuridine antibody. Ligation of excretory ducts caused morphological disorganization of the gland parenchyma, with resultant disapperance of the acini, dilation of the ducts, pronounced fibrosis and infiltration of the inflammatory cells. At seven days after obstruction, the acinar cells shrunk and destroyed partly. However, the intercalated duct cells and the myoepithelial cells were unaffected by ligation. Immunohistochemically, bromodeoxyuridine (BrdU) labeled cells existed scatteringly in the original ducts through the period of duct ligation and unligation studied. In the glands after recanalization following 7 days of the duct ligation, the duct-like structures were recognized a progressive increase. There structures were sigificantly developed in number from 7 to 14 days after the unligation. However, the BrdU-containing nuclei were not almost found in the duct-like structures. At twenty one days after the removal of the obstruction, the regeneration of acinar cells was striking. At 28 days, the acini were almost normal size. In the unligated glands at 21 and 28days, a variable number of BrdU-positive cells was find in acini. At this stage, the constituent cells of the duct-like structures occured many vacuoles and a decrease in their secretory granules was marked. These cells were transformed into intercalated duct cells. These results suggest that the constituent cells of the duct-like structures are altered for intercalated duct cells. The regeneration of acinar cells is the result of cell recovery, not the result of de novo cell differentiation. |
| Practice ： | Dentistry |
| Keywords ： |
