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アブストラクト（51巻1号：神奈川歯学）
Japanese
| Title ： | ポリマイクロバイアルバイオフィルムの代謝活性に対する新規抗菌剤の抗菌効果 |
|---|---|
| Subtitle ： | 神奈川歯科大学学会 第50回総会宿題報告 |
| Authors ： | 富山潔 |
| Authors（kana） ： | |
| Organization ： | 神奈川歯科大学大学院口腔機能修復学講座う蝕制御修復学分野・講師 |
| Journal ： | 神奈川歯学 |
| Volume ： | 51 |
| Number ： | 1 |
| Page ： | 56-60 |
| Year/Month ： | 2016 / 6 |
| Article ： | 報告 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「緒言」渋柿由来の縮合型タンニンは, 一般的に強力なタンパク質凝固作用を持つことで知られているが, ノロウィルスへの効果も謳われており, 舌や歯面上の口腔内細菌数を抑制し, 細菌叢の改善に役立つ可能性がある. 全体的に見て, 植物由来のタンニンは縮合型と加水分解型に分けられ, まずこの両者はpHや成分が大きく異なる. また同じ縮合型の中でも, 種類によって分子量などの構造が全く異なるため, 柿タンニンの口腔内バイオフィルムへの効果は, お茶, ワイン, あるいは他の植物中に含まれるタンニンとは異なると考えられている. 近年, 日本において, 肺炎は, 悪性新生物, 心疾患に次いで死亡原因の第三位となった(厚生労働省平成26年"我が国の人口動態"より). 一般的に高齢者の肺炎の70%が誤嚥に関連していると, 新たに分析されている. また今後, 世界では, 肺癌, 慢性閉塞性肺疾患(COPD), 肺炎が死因の上位を占めるようになると予測される. |
| Practice ： | 歯科学 |
| Keywords ： | ポリマイクロバイアルバイオフィルム, 柿タンニン, 初期齲蝕, 誤嚥性肺炎 |
English
| Title ： | Antibacterial effects of novel antimicrobial agents on the metabolic activity of polymicrobial biofilms |
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| Subtitle ： | |
| Authors ： | Kiyoshi TOMIYAMA |
| Authors（kana） ： | |
| Organization ： | Division of Cariology and Restorative Dentistry, Department of Oral Function and restoration, Graduate School of Dentistry, Kanagawa Dental University |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 51 |
| Number ： | 1 |
| Page ： | 56-60 |
| Year/Month ： | 2016 / 6 |
| Article ： | Report |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract] Pancil PS-M (Rilis Co., Ltd., Osaka, Japan) is a food additive containing condensed tannin extracted from astringent persimmon. The purpose of this study was to investigate the bacterial action of Pancil PS-M on the formation of polymicrobial biofilms by forming biofilms in a high-throughput active attachment biofilm system. Pancil PS-M was dissolved in distilled water and serially diluted for the experiments. Polymicrobial biofilms were cultured on glass cover slips using dilution (×50) of stimulated saliva collected from one healthy adult in a high-throughput active attachment model. Experiments were performed anaerobically in McBain medium, which was refreshed twice daily on a schedule of 10 h and 14 h of growth. Exp. 1: After biofilm formation for 48 h, single treatment was conducted as follows: The specimens (12 per group) were immersed for 5 min in: 0.2% chlorhexidine digluconate (CHX) (Corsodyl, GlaxoSmithKline) (group 0.2C); 0.05% CHX (group 0.05C); 0.5%, 0.7% and 1.0% Pancil PS-M (groups 0.5P, 0.7P and 1.0P); and deionized water (control group). After these treatments, specimens were harvested and CFU counts were analyzed statistically (One-way ANOVA, Tukey's, p<0.05). Exp. 2: After biofilm formation for 24 h, each treatment was conducted as above and then biofilm growth was conducted for 24 h. After the biofilm growth was arrested, the pH of the spent medium was measured at time points of 10 h, 24 h, 34 h and 48 h. The results showed that all treatment groups had a significantly lower CFU than that of the control group. Pancil PS-M showed concentration-dependent inhibition of CFU. Groups 1.0P and 0.2C showed significantly lower CFU levels than those of the other groups. The pH of the spent medium in the 1.0P and 0.2C groups was suppressed compared with that of the control group. These results indicated that Pancil PS-M has efficacy for reducing the risk of disease onset in the oral environment and lungs. |
| Practice ： | Dentistry |
| Keywords ： |
