アブストラクト(17巻1号:神奈川歯学)

神奈川歯学

Japanese

Title : Endotoxin Shockにおける微小循環動態 - pituitary gland, 特にβ-endorphinの関与について -
Subtitle : 原著
Authors : 川崎直則
Authors(kana) :
Organization : 神奈川歯科大学薬理学教室
Journal : 神奈川歯学
Volume : 17
Number : 1
Page : 14-23
Year/Month : 1982 / 6
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「緒言」 顎口腔領域の歯性感染の重大さは, 急性または慢性の感染病巣源として, しかも血行転移を起こす病巣源として, つとに知られているところである. 解剖学的な位置的条件からみても, 口腔は常に感染症と接した状態であり, 刺激の如何でBacteriemiaを起こし, 重篤な症状を随伴することがある. 抜歯後95%に起こるBacteriemia, 口腔外科手術後75%に起こるBacteriemiaは暫間的ではあるが認められ, 体の抵抗性いかんによっては全身性病変に移行する. 最も一般的な, 歯槽膿漏症や根尖性歯周病変などもまた感染病巣であり, 咀嚼または歯石除去のような単純な処置でさえBacteriemiaの発現が認められている. ここに歯性感染の臨床的意義が潜んでいる. 一方, これら感染症の原因も, 医学の進歩により, 従来のグラム陽性菌による外因性感染症にとって変わって, 弱毒菌もしくは非病原菌とされてきた嫌気性菌による内因性感染症に主体が移ってきた.
Practice : 歯科学
Keywords :

English

Title : Microcirculatory Dynamics During Endotoxin Shock - The Role of β-Endorphin Secretes from Pituitary Gland -
Subtitle : Original article
Authors : Naonori YAMAZAKI
Authors(kana) :
Organization : Department of Pharmacology, Kanagawa Dental College
Journal : Kanagawa Shigaku
Volume : 17
Number : 1
Page : 14-23
Year/Month : 1982 / 6
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : Abstract : There is a current growing bady of evidence that the onset of endotoxin shock is associated with a breakdown of the circulatory machinery of the hemodynamics. In our previous report suggested that the clinical treatment for hyperdynamic state during endotoxin shock is important for improvement of the shock. Therefore, the experiment was designed to determine the relationship between the pituitary gland and endotoxin-induced hyperdynamic state, and to investigate the influence of β-endorphin (morphine like substance) secretes from pituitary anterior lobe on the microcirculation during endotoxin shock. In intact rats, the hypotension during the course of endotoxin shock consisted of a rapid fall, a temporary restoration and a slow fall, each occurred in order. Diphenhydramine and naloxone improved the hypotension markedly and prolonged the survival time in endotoxin shock. These effects of diphenhydramine were stronger than those of naloxone. In the microcirculatory dynamics during the course of endotoxin shock, constriction of arteriole and dilation of venule (phase II) following a temporary dilation of arteriole and venule (phase I) were seen. The arteriole and the venule were constricted by naloxone at phase II. In this case, the venule was constricted markedly. In hypophysectomized rats, the temporary restration in blood pressure was not seen during the course of endotoxin shock, and the survival time was significantly shortened compared with the intact rats. Naloxone had no significant effect on the shortened survival time and on the hypotension induced by endotoxin. However, the pretreatment with ACTH or hydrocortisone caused significant marked improvement in the hypotension and in the shortened survival time induced by endotoxin. In this case, the microcirculation was not affected in contrast to what happened in intact rats. The constriction rate of collecting lymphatic vessels was reduced continuously following a temporary increase during the course of endotoxin shock. Naloxone improved the reduction in the constriction rate, but the temporary increase in constriction rate was not affected. Hypophysectomy abolished the temporary increase in the constriction rate. Endotoxin caused a significant increase in ACTH, β-endorphin and histamine in plasma. There was positive correlation between histamine content and ACTH or β-endorphin in plasma. These results suggest the functional antagonistic action between ACTH and β-endorphin is regulated by pituitary gland during endotoxin shock. Further, secretion of ACTH and β-endorphin derive from β-LPH exists in pituitary gland may be mediated by histamine directly or indirectly.
Practice : Dentistry
Keywords :