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アブストラクト（17巻3号：神奈川歯学）
Japanese
| Title ： | マウス顎下腺介在部に対する卵巣摘出およびtestosterone投与の影響 |
|---|---|
| Subtitle ： | 原著 |
| Authors ： | 林弘之, 佐々昭三 |
| Authors（kana） ： | |
| Organization ： | 神奈川歯科大学組織学教室 |
| Journal ： | 神奈川歯学 |
| Volume ： | 17 |
| Number ： | 3 |
| Page ： | 374-384 |
| Year/Month ： | 1982 / 12 |
| Article ： | 原著 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「緒言」 Lacassagne(1940)がマウス顎下腺顆粒管に性的差異のみられることを報告して以来, その意義あるいは発現機序の解明を目的とした多数の研究がなされている. この顆粒管細胞質内の顆粒には, 多くの生理活性物質が含まれており, これらも性ホルモンに依存して変動することが確認されている. マウス顎下腺では, 顆粒管のみでなく介在部導管においても形態学的に雌雄の差異が観察される. 成熟雌マウスの介在部導管は, 細胞質内に顆粒を有する細胞(顆粒性介在部細胞)と無い細胞(無顆粒性介在部細胞)の2種類が存在し, 成熟雄マウスでは顆粒を有する細胞は全く認められない. Gresik(1966)は前者の細胞をgranular intercalated duct cellとし, 後者をnon-granular intercalated duct cellとして報告している. 顆粒性介在部細胞についてYoro(1970)は, 顎下腺の発達初期にのみ出現するterminal tubule cellの遺残したものと推測している. |
| Practice ： | 歯科学 |
| Keywords ： |
English
| Title ： | The Effects of Ovariectomy and Testosterone Injection on the Intercalated Ducts of Mouse Submandibular Glands |
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| Subtitle ： | Original article |
| Authors ： | Hiroyuki HAYASHI, Shozo SASA |
| Authors（kana） ： | |
| Organization ： | Department of Histology, Kanagawa Dental Collge |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 17 |
| Number ： | 3 |
| Page ： | 374-384 |
| Year/Month ： | 1982 / 12 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | Abstract : We investigated the effects of ovariectomy and of injection of testosterone on intercalated duct cells, especially on granular intercalated duct cells in the submandibular glands of adult female mice. Two portions of the intercalated duct are seen : a non-granular portion and a more distal granular portion connecting to acini. Secretory granules in the granular intercalated duct cells are circular, oval or irregularly shaped and have various electron density. The smooth ER have been consistently observed at the luminal surface of the non-granular intercalated duct cells. The submandibular gland, except granular intercalated duct cells, showed no morphological changes by ovariectomy. The number of granular intercalated duct cells, however, decreased, when female mice were castrated. The number of cells in castrated female mice were two-fifth or three-fifth of that in mormal female. Testosterone treatment was also decreased the number of cells of granular intercalated duct. When female mice were castrated and treated by testosterone, the amount of granules decreased and observed smooth ER at the luminal surface of the granular intercalated duct cells. It was demonstrated that intermediate forms between granular and non-granular intercalated duct cells, and granular intercalated duct cells are converted to non-granular intercalated duct cells. These results suggest that the granular intercalated duct cells in the submandibular glands of adult female mice are controlled by estrogen, and the sexual dimorphism is further defined by this study. |
| Practice ： | Dentistry |
| Keywords ： |
