アブストラクト（17巻4号：神奈川歯学）

神奈川歯学

Japanese

Title　： 歯の移動に伴う歯槽骨組織の酵素活性の変化
Subtitle　： 原著
Authors　： 亀井照明
Authors（kana）　：
Organization　： 神奈川歯科大学矯正学教室
Journal　： 神奈川歯学
Volume　： 17
Number　： 4
Page　： 514-524
Year/Month　： 1983 / 3
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 「緒言」 口腔組織の疾病の治療とその予防を目的とする歯科医学のなかで, 矯正学には治療概念としてもまた臨床応用においても, きわだった特色がある. たとえば, 不正位置にある歯あるいは顎の治療に際しては, 矯正力を発揮する装置を口腔内に装着することによって局所組織の改造が進み, 歯あるいは顎の移動が可能となる. すなわち, 矯正学は失われた咬合機能を生物学的に解決しようとする学問的基盤を有していると言える. 用いられる矯正刺激は, 副甲状腺ホルモンやビタミンDなどの全身的な骨代謝調節因子とともに, 骨改造過程に大きな影響を与えている. つまり骨組織は局所に加わる外力に速やかに応答し, その構築を変化させる(Wolff's low)わけである. ビタミンやホルモンなどと骨代謝との関係が明らかになるにつれて, これらと機械的刺激との関係が重要視されてきている. これに対して, 外力が骨構造を変化させる機序に関しては不明な点が多い.
Practice　： 歯科学
Keywords　：

English

Title　： Changes of the Activity of Lytic Enzymes in Alveolar Bone Incident to Orthodontic Tooth Movement
Subtitle　：
Authors　： Teruaki KAMEI
Authors（kana）　：
Organization　： Department of Orthodontics, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 17
Number　： 4
Page　： 514-524
Year/Month　： 1983 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： Abstract : An experiment was carried out to understand biochemical changes of alveolar bone incident to orthodontic tooth movement. Seventy male Japanese white rabbits were used. They were divided into 7 groups. One group was as a control. The helical torsion spring which exerted about 50g expanding force was attached to the maxillary incisors of the each experimental animal. After 1, 2, 4, 7, 14 or 21 days of tooth movement, the animals were sacrificed. The alveolar bones of each group were removed, and freed from soft tissues. Then they were homogenized in a sucrose buffered solution and centrifuged. Supernatants were assayed for the activity of six enzymes ; acid phosphatase, alkaline phosphatase, hyaluronidase, cathepsin B, cathepsin D and collagenase. The analytical results were as follows : 1. Owing to the helical torsion spring, the right and left upper incisors were separated rapidly, and tooth movement continued. The orthodontic tooth movement differed according to three stages. 2. Following the initial tooth displacement, many kinds of enzyme activities elevated above the control level, which suggested that the metabolic changes in the alveolar bone cells were induced by orthodontic stimulation (FIRST STAGE). 3. Cathepsin D and collagenase activities elevated after tooth movement and reached the peak level at 2nd to 4th day (SECOND STAGE), but afterwards they gradually decreased and no more returned to the control level even at 21st day after tooth movement. 4. Acid phosphatase and cathepsin B activities gradually elevated following orthodontic tooth movement till 7th to 14th day (SECOND STAGE), and reached the peak level. 5. Alkaline phosphatase and hyaluronidase activities rapidly elevated at 2nd day after tooth move- ment, and afterwards continued to increase through to 21st day (THIRD STAGE). 6. These findings suggested that the resorption of alveolar bone was shifted to bone formation at 7th day of orthodontic tooth movement, and after that time on active bone remodeling took place.
Practice　： Dentistry
Keywords　：