アブストラクト（18巻1号：神奈川歯学）

神奈川歯学

Japanese

Title　： 67Gaの腫瘍への取り込みおよび体内分布に及ぼす鉄の影響
Subtitle　： 原著
Authors　： 古川恵司
Authors（kana）　：
Organization　： 神奈川歯科大学放射線学教室
Journal　： 神奈川歯学
Volume　： 18
Number　： 1
Page　： 16-32
Year/Month　： 1983 / 6
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 「緒言」 Clausen, Hara(1974)は, 癌患者に静注された67Gaは血液中のtransferrinと結合して, 諸臓器に運ばれると報告した. 以来, 67Gaの代謝に血清鉄値が影響していることが注目された. 1978年, Larsonらは, 腫瘍組胞に67Gaが取り込まれるメカニズムとして, transferrin receptor説を発表し, 腫瘍細胞内に67Gaが取り込まれるためには, まず, 67Ga-transferrin結合が前提であるとのべ, 67Gaと鉄との関係がより具体的なものになった. さきに, 教室の志村は, 担癌マウスを用いて, 67Gaの注射前・後の鉄剤の投与は, 67Gaの腫瘍および各臓器への取り込みに大きな影響を与えることを示唆した. そこで, 今回著者は, 担癌マウスを用いて, 腫瘍および各臓器への67Gaの取り込みが, フェジン(含糖酸化鉄製剤)投与の時間を変えることによって, いかなる影響を受けるかを詳細に検討した.
Practice　： 歯科学
Keywords　：

English

Title　： The Effect of the Administration of Iron on Ga-67 Uptake in Animal Tumor and Biodistribution.
Subtitle　：
Authors　： Keiji FURUKAWA
Authors（kana）　：
Organization　： Department of Radiology, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 18
Number　： 1
Page　： 16-32
Year/Month　： 1983 / 6
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： Abstract : In 1979 Larson reported that the uptake of Ga-67 in tumor cell was preceded by binding of the Ga-67 to transferrin. Since that time there have been many papers concerning changes in Ga-67 accumulation in experimental tumor by administration of iron before and after Ga-67 injection. This study was undertaken in the attempt to discern what changes are produced in Ga-67 images of tumor-bearing rabbits (VX-II) when iron was administered before and after Ga-67 injection. Additionally, the relationships between the change in the serum iron concentration in the tumor tissue in mice bearing Ehrlich's ascites tumor were studied. The following results were obtained. 1) The tumor uptake and biodistribution of Ga-67 following administration of iron in the form of Fesin (saccharated ferric oxide) or ferric-citrate is obviously diminished. This iron administration leads to an elevated excretion of Ga-67 from tumor and other organs except from bone. From this results, it was found that Ga-67 binds somewhat less avidity than iron to various iron transport protein. Accordingly, Ga-67 biodistribution may be markedly influenced by iron-loading. 2) The Ga-67 activity in blood following administration of iron was noted to suddenly markedly decrease. However, 24-48 hours after iron injection the Ga-67 activity in blood gradually increased. This result suggests that the Ga-67 displaced into the extravascular space by iron-loading reentered the vascular space when the iron concentration of serum returned to normal. 3) The accumulation of Ga-67 in the tumor and soft tissues was slightly decreased compared with controls after iron administration. However, the tumor to blood ratio (T/B) of Ga-67 in mice by iron loading was several time greater than that of Ga-67 alone because the clearance of Ga-67 from the blood was more accelated than that of tumor. The large tumor to blood ratio (T/B) would be advantageous in obtaining a more distinct tumor scan.
Practice　： Dentistry
Keywords　：