アブストラクト(18巻1号:神奈川歯学)

神奈川歯学

Japanese

Title : 低濃度フッ化物含有飲料水の骨に与える影響について
Subtitle : 原著
Authors : 浅井康年
Authors(kana) :
Organization : 神奈川歯科大学口腔衛生学教室
Journal : 神奈川歯学
Volume : 18
Number : 1
Page : 33-44
Year/Month : 1983 / 6
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「はじめに」 Bernsteinらのエックス線写真研究によると, 低濃度フッ素飲料水地区住民の間では, フッ素濃度の高い飲料水地区(4~5.8ppm F-)住民にくらべて, 骨多孔症の有病率が明らかに高いことを認めている. この結果は, 以前のLeoneらの報告に対し確証を与えたものと考えられている. これらの研究結果は, フッ素濃度が中程度(4ppm F-以上)である飲料水が骨密度の維持に好ましい影響を与える可能性を示唆している. 一方では, 成人の骨多孔症やPaget病の治療にNaFが有効であることを示唆した報告も多い. しかし, う蝕予防のために僅か1ppm前後という濃度にフッ素を添加またはコントロールした飲料水にも, このような効果が見られるかどうかに関しては, ほとんどわかっていなかった. 例えば, Ansell & Lawrenceはフッ素化地区と非フッ素地区の女性について手および頸部のエックス線診査を行い, フッ素が骨多孔症の有病率を低下させるかどうかは疑問であると述べている.
Practice : 歯科学
Keywords :

English

Title : Possible Effect of Low Doses of Fluoride of Bone in the Rat
Subtitle :
Authors : Yasutoshi ASAI
Authors(kana) :
Organization : Department of Dental Health and Public Health, Kanagawa Dental College
Journal : Kanagawa Shigaku
Volume : 18
Number : 1
Page : 33-44
Year/Month : 1983 / 6
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : Abstract : Since the roentgenographic findings, that prevalence of osteoporosis was higher in residents in low fluoride areas than in those in areas where the natural fluoride content of drinking water was high (4-8ppm F-), were reported, it has been interested that how would be the influence in this respect of drinking water which has been artificially fluoridated to only about 1 ppm. Whereas much less is known of this influence because of limitations on the judging of bone density from radiographs, it was suggested that the higher value in bone mineral content would be related to the fluoridation of drinking water through the direct photon beam absorptiometry. In order to know a possible effect of low doses of fluoride on bone in the rat, an attempt was made to analyze urine samples (excretion of total hydroxyproline, calcium, phosphorus and fluoride), blood serum samples (contents of calcium and fluoride) and femur samples (X-ray diffractometry ;soft X-ray analysis; bone mass; bone strength - stress at fracture; and chemical analysis - contents of calcium, phosphorus and fluoride). Fluoride was administered to rats through drinking water (0, 0.25, 0.5, 1.0, and 3.0 ppm F as NaF) for 105 days. All fluoride groups showed higher values in bone strength, density ratio (density difference between cortical and medullary part of bone), cortical density, cortical thickness, bone diameter and bone mass (bone weight) than those in control group. Moreover, significant positive correlations between bone strength and density ratio or bone mass were found. A slight, but a substantial improvement of crystallinity of bone apatite by increasing doses of fluoride was also found. On the basis of these data, a possible beneficial effect of low doses of fluoride on physical property of bone was suggested.
Practice : Dentistry
Keywords :