- HOME
- > 一般の方
- > バックナンバー：神奈川歯学
- > 18巻1号
- > アブストラクト
アブストラクト（18巻1号：神奈川歯学）
Japanese
| Title ： | モルモットとマウスの脳のオピオイドレセプタサブタイプ |
|---|---|
| Subtitle ： | 原著 |
| Authors ： | 藤澤強 |
| Authors（kana） ： | |
| Organization ： | 神奈川歯科大学薬理学教室 |
| Journal ： | 神奈川歯学 |
| Volume ： | 18 |
| Number ： | 1 |
| Page ： | 54-63 |
| Year/Month ： | 1983 / 6 |
| Article ： | 原著 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「緒言」 1975年Hughesらによりモルヒネ様活性を持ったペプチドが脳から単離され, enkephalinと名づけられた. その後enkephalinの他に種々のオピオイドペプチドの存在が報告されている. また, 脳内でのそれら内在性オピオイドペプチドの局在も, 次第に明らかにされてきている. 一方, オピオイドレセプタの存在は, 1971年に脳内で確認され, 粗ミトコンドリア分画, 特にシナプス膜に富む分画に多いことが知られている. また, オピオイドレセプタを数種類に分類することが出来ることも明らかにされた. 即ち, morphineに親和性の高いミューレセプタ, ketocyclazocineに親和性の高いカッパーレセプタ, [D-Ala2, D-Leu5]enkephalinに親和性の高いデルタレセプタなどである. 口腔領域の疾患を扱う歯科では, 来院患者が疼痛を主訴とする場合が多い. |
| Practice ： | 歯科学 |
| Keywords ： |
English
| Title ： | The Property of Opioid Receptor Subtype in Guinea-Pig and Mouse Brain Homogenates |
|---|---|
| Subtitle ： | |
| Authors ： | Tsutomu FUJISAWA |
| Authors（kana） ： | |
| Organization ： | Department of Pharmacology, Kanagawa Dental College |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 18 |
| Number ： | 1 |
| Page ： | 54-63 |
| Year/Month ： | 1983 / 6 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | Abstract : The heterogeneity of opioid receptors, which was initially suggested by pharmacological experiments on chronic spinal dog, has now been substantiated by in vitro isolated preparations. It has been shown that morphine, a representative mu-receptor agonist, significantly inhibits the electrically-evoked contractions of either guinea-pig ileum or mouse vas deferens while it has no inhibitory action on either rabbit ileum, rat vas deferens or rabbit vas deferens. Additionally, the inhibitory action of morphine on guinea-pig ileum has been shown to be significantly more potent than that on mouse vas deferens. Thus, opioid receptors in one isolated preparation have been shown to be qualitatively and quantitatively different from those in others. Species differences of opioid receptors in the brain, however, have been scarcely studied. Therefore, the properties of opioid receptors in the mouse brain were compared with those in the guinea-pig brain in present investigation. 3H-dihydromorphine, 3H- ethylketocyclazocine, 3H-[D-Ala2, D-Leu5] enkephalin were employed as selective ligands for labeling mu-, kappa-and delta-receptors, respectively. The dissociation constants of three labeled ligand in the homogenates of mouse brain were similar to and were not significantly different from those of guinea-pig brain. The binding maximum of these labeled ligands in the mouse brain, however, was significantly different from that in the guinea-pig brain. Additionally, the IC50 (the concentration of cold ligand to inhibit the binding of labeled to receptors by 50%) values of morphine, ketocyclazocine and [D-Ala2, D-Leu5] enkephalin against these three labeled ligands in the mouse brain were significantly different from those in the guinea-pig ileum. Thus, results in the present study showed that the opioid receptors in the mouse brain were similar in some respects to but were significantly different in other respects from those in the guinea-pig brain. |
| Practice ： | Dentistry |
| Keywords ： |
