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アブストラクト(21巻4号:神奈川歯学)
Japanese
Title : | Potassium Gluconate (K-GL) のラット赤血球解糖系に対する作用機構とK+輸送 |
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Subtitle : | 原著 |
Authors : | 志村公彦, 伊藤春生 |
Authors(kana) : | |
Organization : | 神奈川歯科大学歯科薬理学教室 |
Journal : | 神奈川歯学 |
Volume : | 21 |
Number : | 4 |
Page : | 463-472 |
Year/Month : | 1987 / 3 |
Article : | 原著 |
Publisher : | 神奈川歯科大学学会 |
Abstract : | 「緒言」生体におけるカリウム(K+)の役割が重要であることは, すでによく知られている. 臨床的にも, 慢性腎疾患に対する人工透析, 低K血症の治療などK製剤の応用範囲は広い. また近年, 種々薬剤の繁用にともなう医原性電解質代謝異常が頻繁にみられ, そのうちとくにK+不足, 欠乏が報告されるようになった現状では, 理想的なK+補給剤の必要性が高まっている. 現在まで臨床上, potassium chloride(KCl), potassium aspartate(Asp-K)が使用されてきたが, その後potassium gluconate(K-GL)が開発され, K+の経口的補給剤として注目されるようになった. その理由は, 他剤と比較してKの含量が多い点, 胃腸障害など副作用がない点, 血中K+レベル維持に優れている点にある. 又吉は, 赤血球膜K+輸送が他のカリウム塩(KCl, Asp-K)と比較してK-GLによって著明に増加することを確認し, この効果が血球内解糖系に依存したNa+, K+-ATPaseの活性増加によることを示唆すると同時に, この機構を血中K+レベル維持に関連づけた. |
Practice : | 歯科学 |
Keywords : | K-GL, 赤血球, 解糖系中間体 |
English
Title : | Mechanism of The Effect of Potassium Gluconate (K-GL) on Rat Erythrocyte Glycolysis and Potassium Transport Across The Membrane |
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Subtitle : | |
Authors : | Takahiko SHIMURA, Haruo Ito |
Authors(kana) : | |
Organization : | Department of Pharmacology, Kanagawa Dental College |
Journal : | Kanagawa Shigaku |
Volume : | 21 |
Number : | 4 |
Page : | 463-472 |
Year/Month : | 1987 / 3 |
Article : | Original article |
Publisher : | Kanagawa Odontological Society |
Abstract : | [Abstract]: Selective effect of potassium gluconate (K-GL) on rat erythrocyte glycolysis interacts with active K+ transport across the erythrocyte membrane was investigated. K-GL produced a marked increase in the contents of glycolytic intermediates (i.e., glucose 6-phosphate, G-6-P ; fructose 6-phosphate, F-6-P ; glyceraldehyde 3-phosphate, G-3-P ; 3-phosphoglycerate, 3-PG ; and 2, 3-diphosphoglycerate, 2, 3-DPG), and the contents of F-6-P, G-3-P and 3-PG were drastically increased by K-GL. Further, K-GL which inhibited the effect of methylene blue potentiated the effect of monoiodoacetate on the content of G-3-P. This effect of K-GL was more potent than that of KCl or potassium aspartate (Asp-K). When the rate of methemoglobin reduction was measured to determine the involvement of K-GL in the pentose-phosphate pathway, K-GL was a more effective potassium salt for the reduction than KCl or Asp-K. These results, coupled with other obserbations, now present pharmacological evidence that K-GL enhances active K+ transport across the erythrocyte membrane through acceleration of glycolytic process mainly due to the acceleration of pentose-phosphate path way. Specific increasing effect of K-GL on K+ uptake in the absence of glucose as a substrate and on 2, 3-DPG also pinpoints that K-GL is a useful drug for clinical applications. |
Practice : | Dentistry |
Keywords : | K-GL |