アブストラクト(22巻4号:神奈川歯学)

神奈川歯学

Japanese

Title : Hydroxyapatite-Collage複合体移植の歯周組織に与える影響についての実験的研究
Subtitle : 原著
Authors : 小川優司, 堀俊雄
Authors(kana) :
Organization : 神奈川歯科大学保存学教室第二講座
Journal : 神奈川歯学
Volume : 22
Number : 4
Page : 669-686
Year/Month : 1988 / 3
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「緒言」進行した歯周疾患によって吸収された歯槽骨の再生修復を計るための歯周外科療法として人工骨移植が現在数多く試みられている. その結果, 様々な利点をもつ人工骨移植が垂直性骨欠損に対する処置方法として臨床的に高く評価されているものの, HydroxyapatiteやTricalcium-phosphateを中心としたリン酸カルシウム系骨移植材単独の移植では, 移植部位での歯槽骨再生に限界があり, 多くの実験的研究でも既存の母床骨からの骨伝導能は有するが, あきらかな骨誘導能は認められていない. また, 臨床的にも縫合部からの移植材の漏出という問題が残されている. 一方, biomaterialとしてのコラーゲンについては, そのtype, 構造, 生体内溶解性などをコントロールすることによって, 組織修復, 人工臓器, 細胞培養への応用が試みられており, 現在すでに人工皮膚, 人工粘膜, 骨形成因子の担体, 人工歯根膜などへの応用が検討されている.
Practice : 歯科学
Keywords : 骨移植, ハイドロキシアパタイト顆粒, アテロコラーゲン, 骨欠損, 歯周組織再生

English

Title : Influence of the Hydroxyapatite-Collagen Complex in Artificial Bone Defects to the Periodontal Tissues
Subtitle : Original article
Authors : Yuji OGAWA, Toshio Hori
Authors(kana) :
Organization : Department of Periodontology, Kanagawa Dental College
Journal : Kanagawa Shigaku
Volume : 22
Number : 4
Page : 669-686
Year/Month : 1988 / 3
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : Abstract : The effects of collagen on post-implantation healing of periodontal tissues were studied by implanting a mixture of hydroxyapatite (HAP) and 2% atelocollagen gel (HAP-collagen complex) in artificial bone defects that were produced in the mesial and distal sides of the lower molars of dogs. Six adult mongrel dogs were used in this experiment. Two wall bone defects (8×5×7mm) were experimentally produced after the lower molars were extracted. Simultaneous ligation of the dental necks of the corresponding teeth was performed with orthodontic stainless steel wire to induce experimental periodontitis. HAP-collagen complex was then implanted in the bone defects. Two months later the dogs were sacrificed for histological examination. The HAP alone group and a group without implantation as a control group were then compared with the group in which HAP-collagen complex was implanted under the same experimental conditions. The HAP-collagen complex implantation group showed an increase in new cementum formation, over both the HAP and control group. An increase in the bond between the root surface and gingival connective tissue fibers and the suppression of epithelial downgrowth was found, suggesting that collagen as a biomedical material has a favorable effect on healing of periodontal tissues after periodontal implantation. The number of HAP granules remaining in the bone defects in the HAP-collagen complex implantation group was far larger than that in the HAP alone implantation group, thus showing a favorable result in terms of protection of implant material against leakage.
Practice : Dentistry
Keywords :