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アブストラクト（24巻4号：神奈川歯学）
Japanese
| Title ： | B型肝炎ワクチン接種後における抗体獲得の追跡調査 (I) |
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| Subtitle ： | 原著 |
| Authors ： | 木村友七*1,*2, 岩宮万里子*1,*2, 吉田直美*1,*2, 岩本朗子*1,*2, 笹田睦美*1,*2, 伊東利*1,*2, 菊池信弥*1,*2, 八木伸*1,*2, 重根充*3, 檜垣旺夫*3 |
| Authors（kana） ： | |
| Organization ： | *1神奈川歯科大学臨床病理学教室, *2神奈川歯科大学臨床検査科, *3神奈川歯科大学小児歯科学教室 |
| Journal ： | 神奈川歯学 |
| Volume ： | 24 |
| Number ： | 4 |
| Page ： | 730-734 |
| Year/Month ： | 1990 / 3 |
| Article ： | 原著 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「はじめに」 ワクチンの投与は, Jennerの天然痘, Sabinの生ポリオ・ワクチン, わが国での北里氏らの努力がある. 病院内感染は発生要因を検討した対策が必要であり, 肝癌とB型肝炎ウイルス(HBV)との関連が密接で, 妊婦のHBe抗原・抗体と児の病態との関係について, 岡田・真弓ら, Sehweitzerらにより報告されてきた. 母子間感染防止対策事業が, 昭和60年に初められてからキャリアの発症は減少した. 古い記憶ではあるが, 体の中には外界からの侵入に備える種々の防御機構があるが最も高度な仕組みは免疫現象である. また, 免疫現象で重要な役割となる抗体は, あらゆる侵入体に対してそれぞれ特異的に反応し得る多様性を備えているなどである. B型肝炎の本態も解明され感染様式や感染経路も明らかになり感染の予防・防止をする免疫グロブリンやワクチン製剤が開発されてB型肝炎は防止でき得る疾患となった. 本学でも病院関係医療従事者におけるHB予防ワクチンを接種希望者に実施した. |
| Practice ： | 歯科学 |
| Keywords ： | HBワクチン, HBs抗体, 追跡調査 |
English
| Title ： | Follow up Study on Anti-HBs Levels in Vacciness After Two and Three Doses of HB Vaccine (I) |
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| Subtitle ： | |
| Authors ： | Tomoshichi KIMURA, Mariko IWAMIYA, Naomi YOSHIDA, Akiko IWAMOTO, Mutsumi SASADA, Satoshi ITO, Nobuya KIKUCHI, Shin YAGI, Mitsuru SHIKONE*, Morio HIGAKI* |
| Authors（kana） ： | |
| Organization ： | Department of Clinical Pathology and Clinical Laboratories, Kanagawa Dental College, *Department of Pedodontics, Kanagawa Dental College |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 24 |
| Number ： | 4 |
| Page ： | 730-734 |
| Year/Month ： | 1990 / 3 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract]: An HB prophylaxis vaccination that included a primary and secondary vaccination was carried out on persons working at this university hospital. In the primary vaccination, the subjects were inoculated the second time with a vaccine derived from human blood plasma obtained from the Kitazato Therapeutic Research Institute. The third time, they were inoculated with a vaccine from the Chemo-Sero Therapeutic Research Institute derived from a second-generation vaccine organized ferment. The vaccine used for the second inoculation was obtained from the Chemo-Sero Therapeutic Research Institute. [Results]: A total of 254 subjects were inoculated with the HB prophylaxis vaccination. 1. Of the 216 subjects inoculated with the primary vaccination, at the time of the second inoculation, 65 subjects (30 %) tested positive for antibodies 3-4 months following inoculation. There was an especially high rate among females between 20 and 50 years. Thirty-two subjects (15 %) tested positive 15-16 months following inoculation with a high rate among females. 2. Among 132 subjects inoculated the third time with the primary vaccination (those who tested negative in the second inoculation of the above vaccine), 76 subjects (58 %) tested positive for antibodies 8-9 months following inoculation with a generally high rate among females. Thirty-five subjects (27 %) tested positive 15-16 months after inoculation with a high rate among females between 20 and 30 years and among males between 40 and 60 years. 3. Among the 38 subjects who were inoculated the second time with the secondary vaccination, 8 subjects (21 %) tested positive for antibodies 5 months following inoculation, with a high rate among females in their 20's. |
| Practice ： | Dentistry |
| Keywords ： |
