アブストラクト（25巻1号：神奈川歯学）

神奈川歯学

Japanese

Title　： B型肝炎ワクチン接種後における抗体獲得の追跡調査 (II)
Subtitle　： 原著
Authors　： 木村友七*1,*2, 岩宮万里子*1,*2, 吉田直美*1,*2, 岩本朗子*1,*2, 笹田睦美*1,*2, 伊東利*1,*2, 菊池信弥*1,*2, 木本椿作*3
Authors（kana）　：
Organization　： *1神奈川歯科大学臨床病理学教室, *2神奈川歯科大学臨床検査科, *3神奈川歯科大学予防歯科学教室
Journal　： 神奈川歯学
Volume　： 25
Number　： 1
Page　： 109-114
Year/Month　： 1990 / 6
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 「はじめに」 B型肝炎ウイルス(HBV)は, Blumberg (1965)らによるヒト血清中に未知のリポタンパク質(Au抗原)が報告された. HBV感染が予測される人為的事故に対する免疫グロブリン(HBIG)やB型肝炎ウイルスワクチン(HBワクチン)の投与と接種を含めた感染予防法よりないが, 基本的対処方法による予防手段と個々の体調らのコントロールが必要である. HBワクチンには, 第1世代ワクチン(血漿由来)と第2世代(酵母菌由来)が実施されている. 新ワクチンとして利用できる報告には5,6)が検討されている. HBワクチン接種におけるHBs抗体価の長期観察とワクチン追加接種時の検討, HBワクチンと免疫グログリン同時投与によるHBs抗体産生の誘導と非応答者(non-responder, 以下NR)への応用, 北研製および化血研製HBワクチンの接種における現況らの接種報告は多数なされているがほかの報告は割愛した.
Practice　： 歯科学
Keywords　： HBワクチン接種, 免疫, 抗体獲得

English

Title　： Follow up Study on Anti-HBs Levels in Vacciness After Two and Three Doses of HB Vaccine (II)
Subtitle　：
Authors　： Tomoshichi KIMURA, Mariko IWAMIYA, Naomi YOSHIDA, Akiko IWAMOTO, Mutsumi SASADA, Satoshi ITO, Nobuya KIKUCHI, Shunsaku KIMOTO*
Authors（kana）　：
Organization　： Department of Clinical Pathology and Clinical Laboratories, Kanagawa Dental College, *Department of Preventive Dentistry, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 25
Number　： 1
Page　： 109-114
Year/Month　： 1990 / 6
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract]: An HB prophylaxis vaccination that included a primary and secondary vaccination was carried out on persons working at the university hospital. In the primary vaccination group, the subjects were inoculated the second time with a vaccine derlived from human blood plasma obtained from the Kitazato Therapeutic Research Institute. The third time, they were inoculated with a vaccine from the Chemo-Sero Therapeutic Reseach Institute derived from a second-generation vaccine organized ferment. The vaccine used for the second inoculation group was obtained from the Chemo-Sero Therapeutic Research Institute. Results were summarized as follows : 1) The primary vaccination group : (1) The number of the 153 subjects inoculated with the primary vaccination at the time of the second inoculation, 49 subjects (32%) tested positive for antibodies 3-4 months following inoculation. Thirty-two subiects (20%) tested positive 15-16 months following inoculation with a high rate among females. (2) Among 104 subjects inoculated the third time with the primary vaccination (those who tested negative the second inoculation of the above vaccine), 61 subjects (58.7%) tested positive for antibodies 8-9 months following inoculation with a generally high rate among females. Twenty-eight subjects (26%) tested 15-16 months after inoculation with a high rate among females between 20 and 30 years and among males between 40 and years. 2) The secondary group : Among the 38 subjects who were inoculated the second time with the secondary vaccination, 8 subjects (21%) tested positive for antibodies 5-6 months following inoculation, with a high rate among females in their 20's. 3) The rate of antibodies formation. (1) The period of antibodies acquistion of the cases with higher antibodies titer tended to last longer. (2) Younger persons and females showed a higher rate of antibodies formation.
Practice　： Dentistry
Keywords　：