アブストラクト(25巻3号:神奈川歯学)

神奈川歯学

Japanese

Title : Hamster Cheek Pouch微小循環系における血管反射
Subtitle : 原著
Authors : 若杉好文, 伊藤春生
Authors(kana) :
Organization : 神奈川歯科大学歯科薬理学教室
Journal : 神奈川歯学
Volume : 25
Number : 3
Page : 284-291
Year/Month : 1990 / 12
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「緒言」 血圧が一時的に, 急激に上昇した場合, arterioleの収縮でcapillaryへの血液流入が防御される現象は古くから知られている. 同様に, 静脈側の血行障害が生じた場合でも, arterioleの収縮がcapillary内の鬱血を排除する方向に血行を調節している. このようにcapillary内の一部の血行変化は, arterioleとその分岐部の収縮・拡張によって調節されているが, この機構についての明確な説明に乏しい. 部分的には, 脊髄を介するlong pathの反射と脊髄を介さないshort pathのaxon reflex, いわゆるcapillary reflex(毛細血管反射)として説明される. capillaryからcapillaryへの反射は, カエルの両下肢の蹼膜微小血管を用い, 一側蹼膜epinephrineを滴下することで生ずるcapillaryの収縮に対して, 無処置対側の蹼膜arterioleとその分岐部が約5秒の潜時で収縮を起こし, これが一側の坐骨神経切断により消失することから支持されるようになった.
Practice : 歯科学
Keywords : Hamster cheek pouch, 微小循環, 血管反射, 湿度, pH

English

Title : Vascular Reflex in Microcirculation of Hamster Cheek Pouch Model
Subtitle :
Authors : Yoshifumi WAKASUGI, Haruo Ito
Authors(kana) :
Organization : Department of Pharmacology, Kanagawa Dental College
Journal : Kanagawa Shigaku
Volume : 25
Number : 3
Page : 284-291
Year/Month : 1990 / 12
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract]: The vascular reflex in hamster cheek pouch model was studied. When temperature of the superfusing solution was changed from 37℃, diameter of small artery was increased up to 45℃ ; instead, the diameter was decreased at the temperature below 37℃ to 14℃. These responses of small artery were temperature-dependent. The dilatation of small artery by increasing or decreasing pH from 7.35 was demonstrated. The pH-dependent response of the small artery was found over the pH range of 7.0-8.5 or of 7.0-5.85. By the temperature (45℃ and 14℃) or pH (8.5 and 5.85) stimulation of the cheek pouch preparations, the small artery in opposite preparation superfused at 37℃ or at pH 7.35 was responded after a few minute latency in a manner analogous to that seen in the stimulated cheek pouch preparations. The reflex dilatation produced by the stimulation with pH 5.85 was significantly inhibited by the treatment of hamster with atropine, suggesting that the vascular reflex are from the stimulated preparations to opposite non-stimulated preparations may be the long path reflex at least in part via parasympathetic nerves. It is also demonstrated that the potency of the sensitivity of the microvessels to pH and temperature changes is in following orders : small artery (A1) > arteriole (A2) > terminal arteriole (A3) and A2 = A3 > A2, respectively.
Practice : Dentistry
Keywords : Hamster cheek pouch, pH