アブストラクト（25巻4号：神奈川歯学）

神奈川歯学

Japanese

Title　： MRL/1prマウス(リンパ球増殖遺伝子と自己免疫)の口腔領域に発現する動脈炎の形成機序についての免疫病理学的研究 - 特にその組織学的病態と遺伝的背景について -
Subtitle　： 原著
Authors　： 窪田展久, 渡辺是久
Authors（kana）　：
Organization　： 神奈川歯科大学口腔病理学教室
Journal　： 神奈川歯学
Volume　： 25
Number　： 4
Page　： 419-438
Year/Month　： 1991 / 3
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 「緒言」 MRL/1prマウスは, Jackson研究所の故Murphy博士らによって確立されたmurine lupus(自己免疫疾患自然発症系マウス)で, 本マウスの特徴は常染色体上の劣性遺伝子である1pr遺伝子(lymphoproliferative gene)によって発現する異常T細胞の増殖である. この異常T細胞はB cell differentiated factor(BCDF)を産生放出することによりB cellのhyperfunctionを惹起し, 多量の免疫複合体や抗gp70を産生することが知られている. これらの局所への沈着によって免疫複合体型腎炎や肉芽腫性血管炎(動脈炎)をはじめとした様々な臓器障害の発現が認められ, 現在, 世界中の研究者によって多彩な病変が提示されている. 当教室においても渡辺・宮本らは本マウスに自然発症する顎下腺炎が1pr遺伝子の発現による増殖性異常Tリンパ球の顎下腺実質内への浸潤にはじまり, その後, 形質細胞やマクロファージを混ずる炎症細胞浸潤巣へと進展し, この炎症巣内にIII型アレルギー反応による動脈炎を惹起するという, 本マウスの顎下腺炎が免疫異常に基づく免疫複合体病の一分症であることを明らかにしている.
Practice　： 歯科学
Keywords　： MRL/1prマウス, 動脈炎, マクロファージ

English

Title　： Immunohistochemical Study of Arteritis in Oral Organs or MRL/1pr Mouse (Lymphoproliferative Gene and Autoimmunity)
Subtitle　：
Authors　： Nobuhisa KUBOTA, Yoshihisa Watanabe
Authors（kana）　：
Organization　： Department of Oral Pathology, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 25
Number　： 4
Page　： 419-438
Year/Month　： 1991 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] In the study of the oral lesions which occured spontaneously in mice with abnormal proliferation of T lymphocytes as the result of expression of the 1pr gene, the pathological differences between the arteritis in the submandibular gland and that in the tongue were found. In this study, these differences were investigated histopathologically, immunohistochemically, and electronmicroscopically, and the mechanism of onset of these lesions was discussed. 1. In the submandibular gland, arteritis occured in the inflammatory foci with infiltration of lymphocytes and plasma cells. 2. Arteritis in the tongue occurred on the wall of artery with a relatively wide diameter, and gave the findings of granulomatous arteritis accompanied with marked proliferation of macrophages over the area the intina to the adventitia. Inflammatory cellular infiltration precedent to the granulomatous arteritis was not observed. 3. Immunohistochemical examination revealed the deposit of immune complexes and complement component (C3) along the arterial internal space in the arteritis in the submandibular gland. On the other hand, arteritis in the tongue showed localized deposit of immune complexes and the complement component (C3) along the arterial internal space while there were observed immune complexes englobed in the macrophages which had infiltrated on the adventitial side and marked deposit of the complement component (C3) in the perivascular area of the supplying vessels in the granulomatous lesions. The above-mentioned results suggested that in the arteritis in the submandibular gland the type-III allergic reaction caused by activation of the immune complexes and the complement component (C3) deposited in the lumen may play an important role in the onset of arteritis in the submandibular gland. On the other hand, arteritis in the tongue may have occured owing to the abnormal function of macrophages, an immunological abnormality of the mice, in combination with the type-III allergic reaction. Thus the mechanisms of the two kinds of arteritis may be different from each other for the reasons including the difference in the genetic background.
Practice　： Dentistry
Keywords　：