アブストラクト（27巻1号：神奈川歯学）

神奈川歯学

Japanese

Title　： 口腔粘膜癌周辺異常上皮に関する研究 - 臨床病理像と核DNA量による検討 -
Subtitle　： 原著
Authors　： 河原健司, 志村介三
Authors（kana）　：
Organization　： 神奈川歯科大学口腔外科学教室第二講座
Journal　： 神奈川歯学
Volume　： 27
Number　： 1
Page　： 30-42
Year/Month　： 1992 / 6
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 「緒言」口腔粘膜癌の周辺に, 肉眼的または組織学的に種々の異常がみられることが知られている. しかし, その生物学的性状や意義については不明な点が多い. これらの異常上皮については, 1)癌の一部, 2)癌発生の母地, 3)癌発生により二次的に生じたもの, 4)癌との単なる併存, などの可能性が考えられている. なかでも悪性潜在能の問題は癌の治療法や治療範囲を決めるうえで, 臨床的に極めて重要な問題である. この点について, これまで主に臨床的ならびに病理組織学的所見を中心に検討されてきたが, 結論を得るには至っていない. 本研究では, 従来の検索に加え, 細胞増殖や遺伝情報に関係し細胞機能の中心的役割をもつ核DNAの定量, 解析を行い, 口腔粘膜癌の周辺異常上皮の性状と意義について検討した.
Practice　： 歯科学
Keywords　： 異常上皮, 口腔粘膜癌, 核DNA量, DNA ploidy pattern, 顕微分光測光

English

Title　： Study on the Abnormal Mucous Membranes around Carcinoma of the Oral Mucosa - Clinicopathological Findings and Nuclear DNA Contents -
Subtitle　：
Authors　： Kenji KAWAHARA, Kaizo Shimura
Authors（kana）　：
Organization　： The Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 27
Number　： 1
Page　： 30-42
Year/Month　： 1992 / 6
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： Abstract: Clinical and pathologial studies were performed on 31 cases from 45 lesions with abnormal mucous membranes around squamous cell carcinoma of oral mucosa, and nuclear DNA in the relevant cells was quantified. The following results were obtained. 1) Cases whose primary tumor was at a stage equal to or less than T2 in size were most frequent (87.1%), while on a histopathological findings, the squamous cell carcinoma of well differentiated type with mildly cellular atypia were commonest (87.1%). 2) Visual inspection of abnormal mucous membranes around carcinoma reveals that leukopathic type were the most common (67.7%), followed by a mixture of leukopathic and erythromatous type (16.1%), and verrucous type (6.5%). 3) Regarding the positional relationship between carcinomas and abnormal mucous membranes, the cases (type I) in which a carcinoma was present within the confines of the abnormal mucous membranes were most frequent (48.4%), followed by a second group (type II) in which the two were opposed to each other (32.3%), by a third group (type III) in which the two were separated each other (6.4%), and by a fourth group in which types II and III were intermingled (12.9%). 4) When classified on a histopathological basis, the abnormal mucous membranes lacking dysplasia accounted for l2.9%, those with slight dysplasia, 51.6%, those with moderate dysplasia, 19.4%, and those with severe dysplasia, 16.1%. 5) Regarding the DNA ploidy pattern, diploidy pattern was observed in 30.4% of the carcinoma cells studied and aneuploidy pattern was observed in 69.6% of the cases while the equivalents for abnormal mucous membranes cells were 54.2% and 45.8%, respectively. 6) Generally speaking, the frequency of the abnormal mucous membranes cells with a variation and exceeding 4C with respect to nuclear DNA content is at a midpoint between the corresponding values for the carcinoma cells and the normal epithelial cells. However, in the four cases with a diploidy pattern and in the five cases with an aneuploidy pattern, the frequency of cells exhibiting a variation and exceeding 4C was below the lower limit observed in carcinoma cells. 7) No apparent correlation was observed between the presence of dysplasia and the DNA ploidy pattern of the cells involved. Dysplastic cells showed a higher frequency of cells with a variation and exceeding 4C with respect to the nuclear DNA content than did non-dysplastic cells. however, when the frequency was compared in terms of severity of dysplasia, no significant differences were observed. On the basis of the above it is likely that the abnormal mucous membranes around carcinoma of oral mucosa may act as a basis of development from which such tumors are generated, and that the mucous membranes which have a higher frequency of cells with an aneuploidy pattern or a variation and exceeding 4C with respect to nuclear DNA content, suggest a strong potentiality to change malignancy.
Practice　： Dentistry
Keywords　： DNA ploidy pattern