アブストラクト(29巻4号:神奈川歯学)

神奈川歯学

Japanese

Title : 人工骨移植後の歯周組織再生に関する研究 第1報 : 非吸収性材料Hydroxyapatite (HAP) 移植後の血管および骨変化について
Subtitle : 原著
Authors : 渕田恒晴*, 菅谷彰*, 松尾雅斗**, 堀俊雄*, 高橋和人**
Authors(kana) :
Organization : *神奈川歯科大学歯科保存学教室第II講座, **神奈川歯科大学口腔解剖学教室
Journal : 神奈川歯学
Volume : 29
Number : 4
Page : 287-308
Year/Month : 1995 / 3
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「緒言」 歯周疾患により失われた歯周組織を回復する方法として, 各種生体材料を使用した再建療法が行われている. 本論文では一般臨床において広く使用されている骨移植材の一つとしてHydroxyapatite(HAP)を選び, その組織再生について血管系を中心として観察した. HAPは骨伝導能を有するとされ, 骨欠損部に充填されると再生してくる骨組織により取り囲まれる. そして骨組織と直接結合することにより, 骨添加が増生され材料自身は組織内に残存する. 本論文は第1報として移植材が組織内に残存するHAPを, 第2報では移植材が組織内で吸収するTricalcium Phosphate(TCP)について観察し, その両者を比較, 検討した. 過去の報告でLevinは骨移植材の条件の中で, 1)骨形成を促進する 2)セメント質形成を促進し歯根との再付着を生じさせる 3)生体親和性が高くかつ発癌性, 毒性, 抗原性, 起炎性がない必要があると述べた.
Practice : 歯科学
Keywords : 歯周組織, HAP, 血管鋳型法, 走査型電子顕微鏡

English

Title : The Study of Regenerating Process after Implanation of Hydroxyapatite (HAP) I. Changes of Vascular Architecture and Bone Remodeling in Periodontal Tissue using Resin Cast Method
Subtitle : Original article
Authors : Tsuneharu FUCHIDA*, Akira SUGAYA*, Masato MATSUO**, Toshio Hori*, Kazuto Takahashi**
Authors(kana) :
Organization : *Department of Periodontology, Kanagawa Dental College, **Department of Oral Anatomy, Kanagawa Dental College
Journal : Kanagawa Shigaku
Volume : 29
Number : 4
Page : 287-308
Year/Month : 1995 / 3
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : Abstract : Hydroxyapatite (HAP) granules is frequently used in periodontal surgical therapy, which was implanted to study the participation of the bone and vascular regeneration. Three wall bony defects were created artificially in the mandibular molars (Artificial bone defect) of 6 adult mongrel dogs for this experiment. Experimental group was filled the HAP tightly into the Artificial bone defect and control group was no-filling. After seven, 30 and 90 days, animals were sacrificed, then vascular corrosive resin cast method, scanning electolon microscopy (SEM) and histological observation using India ink method were done. The results were as follows ; 1) Control group ; After 7 days, vascular network in the defect and regenerated bone from surrounded tissue were observed. 30 days later, Artificial bone defect was filled by newly formed bone, and bone trabecular pattern was also observed at 90 days. 2) Experimental group ; Vascular network among the HAP granules and newly formed bone at the bottom of Artificial bone defect were observed at 7 days. After 30 days, the Artificial bone defects were filled by granules and newly formed bone which regenerated in between the granules and blood vessels. Newly formed bone was directly connect to granules. 90 days later, bone Newly formed in the Artificial bone defect was calcified more than the control group at same time. A few blood vessels were still arranged in bone tissue which was formed inbetween the HAP granules. We conclude which the HAP granules remain in the bony defect and directly connect to new bone tissue, and this pattern shows vascularly formation first then bone by osteoconduction.
Practice : Dentistry
Keywords : HAP