アブストラクト（32巻1号：神奈川歯学）

神奈川歯学

Japanese

Title　： 抜歯創の治癒過程における骨形成および血管構築の変化に関する研究
Subtitle　： 原著
Authors　： 大原健一, 高橋和人
Authors（kana）　：
Organization　： 神奈川歯科大学口腔解剖学教室
Journal　： 神奈川歯学
Volume　： 32
Number　： 1
Page　： 69-88
Year/Month　： 1997 / 6
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 「緒言」 抜歯創の治癒過程に関する形態学的研究には, (1)骨性治癒経過に重点を置いてX線学的に検索したもの, (2)病理組織学的または組織化学的に抜歯創内(特に開放性抜歯創)における肉芽組織変化を経時的に検索したもの, (3)マイクロアンギオグラフィーと透明標本を併用して血管新生について検索したもの, (4)オートラジオグラフィーやマイクロラジオグラフィーを併用し, 無機成分の消長について検索したもの, さらに, (5)テトラサイクリンやカルセインなどのラベリング剤を用いた硬組織時刻描記法により検索したものなど, これまで数多くの先人による報告がなされてきた. これらの多くは組織切片を主体とした光学顕微鏡レベルで, 抜歯創における血管新生過程や新生骨の形成, および骨改造現象などを扱ったものである. 近年, 走査型電子顕微鏡(以下SEMと略す)による各種組織を細胞・生物学的に立体的視野から検討することができるようになってきた.
Practice　： 歯科学
Keywords　： 抜歯創, 歯槽骨, 血管鋳型, 走査型電子顕微鏡, ラベリング法

English

Title　： Osteogenesis and Changes of Vasculature during the Healing of Extraction Wounds
Subtitle　： Original article
Authors　： Kenichi OHARA, Kazuto Takahashi
Authors（kana）　：
Organization　： Department of Oral Anatomy, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 32
Number　： 1
Page　： 69-88
Year/Month　： 1997 / 6
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] To determine the relationship between osteogenesis and changes in vascularity during the healing of extraction wounds, we extracted the mandibular third molars in adult dogs and investigated the time-course of histological changes under a light microscope, scanning electron microscope, and fluorescent microscope. The following results were obtained. Seven days after extraction, fibroblasts and newly formed blood vessels were found to arise from the bottom of the extraction socket and extend in a perpendicular direction to the socket margin, which contained a blood clot. Leakage of injected plastic resin was found at sites of newly formed blood vessels. The bone formation form the socket wall in responce to the healing was observed in a lamellar fashion ; the osteogenesis was especially remarkable at the socket base. Two weeks after extraction, appearence of fibroblasts and the newly blood vessels formation at the alveolar wall coused toward the socket center, and the blood vessels formed a loop at the edge of the trabeculae developed in response to healing. There was a newly formed bone, which had a honeycomb-like pattern and extended into the vascular network from the socket wall to the tip of the vascular loop. The diameter of the veins in the alveolar bone that communicated with the extraction socket increased gradually. Four weeks after tooth extraction, there were additional signs of newly formed trabeculae, which had increased in thickness, and the blood vessels in the region had decreased in diameter and communicated at the socket center. Seven weeks after extraction, the bone at the alveolar crest had been absorbed, creating a depression. The newly formed trabeculae at the socket opening were densely packed and had formed a lamellar structure. The newly formed trabeculae developed further at the socket base with remarkable remodeling mainly at the site of resorption of the alveolar wall. The bone showed increased porosity ; the corresponding blood vessels formed a sinus-like pattern in the marrow. The results demonstrate that the interaciton of newly formed blood vessels with existing blood vessels around the extraction socket plays important roles in the formation and remodeling of bone during the healing of extraction wounds. It is also suggested that the vascular pattern formed in response to the healing would be one of the factors determining the structure and rate of remodeling of bone.
Practice　： Dentistry
Keywords　：