アブストラクト（36巻4号：神奈川歯学）

神奈川歯学

Japanese

Title　： 吸収性人工骨移植後の歯周組織および血管再生に関する形態学的研究
Subtitle　：
Authors　： 天野好之, 松尾雅斗, 中村社綱*
Authors（kana）　： あまのよしゆき, まつおまさと, なかむらたかつな
Organization　： 神奈川歯科大学口腔解剖学教室, *神奈川歯科大学歯科補綴学講座
Journal　： 神奈川歯学
Volume　： 36
Number　： 4
Page　： 189-206
Year/Month　： 2001 / 12
Article　： 原著
Publisher　： 神奈川歯科大学学会
Abstract　： 近年, インプラント治療の普及とともに, 狭小あるいは高さの低い顎骨を増成することを目的として, 各種の骨移植が行われるようになってきている. これらの骨増成療法は人工骨の持つ骨伝導能を足掛かりとして骨組織の再生を行うもので, 天然骨, 人工骨を含め様々な素材と方法が考案されている. 自家骨移植(Autograft)は患者自身の骨を用いる移植法で骨増成の他, 歯根膜やセメント質の形成も可能であると言われている1, 2). 移植する骨は口腔内では上顎結節や治癒過程にある抜歯窩, オトガイ部などから採取され, 海綿骨と骨髄, 緻密骨の単独またはそれらを混合した組み合わせで用いられている. また, 口腔外からは, 主に腸骨から移植骨が採取される. 患者以外の天然人骨を用いる他家骨移植(Allograft)は, 組織バンクからの入手が可能である3). 骨を凍結乾燥させることでその抗原性を低下させ4, 5), 未脱灰凍結乾燥同種骨(Undemineralized freeze dried bone allograft;FDBA)や脱灰凍結乾燥同種骨(Demineralized freeze dried bone allograft;DFDBA)が作製され試みられたこともある.
Practice　： 歯科学
Keywords　： 人工骨移植, 血管鋳型法, 微小循環, TCP

English

Title　： Morphological Study on Regenerating Processes of Bone and Vasculature after Bonegraft Using Biodegradable Synthetic Material
Subtitle　：
Authors　： Yoshiyuki AMANO, Masato MATSUO, Takatsuna NAKAMURA*
Authors（kana）　：
Organization　： Department of Oral Anatomy, Kanagawa Dental College, *Department of Prosthodontics, Kanagawa Dental College
Journal　： Kanagawa Shigaku
Volume　： 36
Number　： 4
Page　： 189-206
Year/Month　： 2001 / 12
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： Synthetic hone graft is one of the feasible periodontal therapies to restore the loss of alveolar bone. In this study, bio-degradable synthetic bone material was applied to extraction sockets of the beagle dog. To elucidate the relationship between the bone formation and vascular changes, a vascular resin cast model was examined under a scanning electron microscope (SEM). Six beagle dogs were used as experimental animal. After extraction of the premolars, synthetic bone graft material, tricalcium phosphate (TCP) was implanted in the sockets. Vascular resin cast model was made at 30, 60 and 90 days post-operation, by injecting low-viscosity synthetic resin into the inferior alveolar artery and the model was observed under SEM. Non-decalcified histological grind section was also examined under a microscope. At 30 days post-operation, the TCP granules tightly filled in the extraction sockets. Newly formed blood vessels from the pre-existing bone marrow penetrated the spaces between the granules in the socket. These blood vessels consisted of vascular buds. New bone was formed along the pre-existing bone and granular space. At 60 days post-operation, resorption of the TCP granules emerged. Enlarged granular spaces were filled with newly formed bone. Blood vessels with large diameter from the pre-existing bone marrow were bifurcated in the sockets and fine blood vessels formed a network around the granules. At 90 days post-operation, almost all of the TCP granules were resorbed. The regenerated bone structure which consisted of compact bone and spongy bone appeared at this stage. Vascular network of bone marrow was rearranged and bone trabeculae were reproduced. In the control group, the regenerated alveolar crest was lower than the pre-existing alveolar ridge. However, in the TCP grafted group, the height of the alveolar crest is recovered to the level of the pre-existing alveolar ridge. It was presumed that TCP granules could act as guide for the newly generated bone. These findings suggest that TCP is a useful material for alveolar bone reconstruction. It is also postulated that vascular regeneration dynamics may modify bone regeneration.
Practice　： Dentistry
Keywords　：