アブストラクト（50巻2号：神奈川歯学）

神奈川歯学

Japanese

Title　： 歯科治療で使用する青色光による生体への影響
Subtitle　： 特別研究員報告
Authors　： 吉田彩佳
Authors（kana）　：
Organization　： 神奈川歯科大学大学院歯学研究科口腔科学講座光歯科医学分野
Journal　： 神奈川歯学
Volume　： 50
Number　： 2
Page　： 103-107
Year/Month　： 2015 / 12
Article　： 報告
Publisher　： 神奈川歯科大学学会
Abstract　： 「はじめに」青色発光ダイオード(light emitting diode; LED)を発明した3人の物理学者にスウェーデン王立化学アカデミーは2014年のノーベル物理学賞を授与した. 授与の公式理由は, 赤崎勇(名城大学)教授と天野浩(名古屋大学)教授, 中村修二(米カリフォルニア大学サンタバーバラ校)教授が「効率的な青色LEDを発明し, 明るく省エネルギーな白色光源を可能とした」ためとある. 歯科においては, 省エネルギー, 低コストに高出力の青色光を使用することが可能なことから, 現在では従来のハロゲン(quartz tungsten halogen; QTH)光に代わり歯科臨床の現場において, コンポジットレジン修復やオフィスブリーチングなどの処置に欠かせないツールとして広く応用されている. 電磁波のうち, ヒトの目で見える波長は可視光線と規定され, 最も短い380～495nmの波長を青色光と呼ぶ.
Practice　： 歯科学
Keywords　： 青色光, 歯科用光照射器, 酸化ストレス, 活性酸素種

English

Title　： Impact on the living body by the blue light to be used in dental treatment[Machine Translation] (歯科治療で使用する青色光による生体への影響)
Subtitle　：
Authors　： Ayaka YOSHIDA
Authors（kana）　：
Organization　： Division of Photomedical Dentistry, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University
Journal　： Kanagawa Shigaku
Volume　： 50
Number　： 2
Page　： 103-107
Year/Month　： 2015 / 12
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] In recent years, blue light has attracted much public attention since the development of the blue light-emitting diode (LED). The adverse effects of blue light irradiation on the retina are already becoming a problem in ophthalmology. Age-related macular degeneration is caused by excited blue light which induces oxidative stress by generating reactive oxygen species (ROS). Therefore, antioxidants are administered and/or functional glasses that cut blue light wavelengths are used to protect against blue light irradiation. On the other hand, in the dental field, since the development of a visible light-cured composite resin, blue light has been applied in clinical treatment. Blue light is also used for direct bonding and/or tooth bleaching. Blue light has been considered a safe wavelength like visible light, and has been used without investigating the effects of conventional blue light wavelength irradiation on the living body. We have studied the influence of blue light irradiation used in dental treatment. We firstly found that blue light irradiation induces apoptosis due to inhibiting the proliferative activity of vascular smooth muscle cells and the oxidative stress involved in this phenomenon. In addition, it has been found that blue light irradiation also induced ROS generation in vascular smooth muscle, and that vascular smooth muscle contracted in response to noradrenaline induced by ROS. Furthermore, in the gingival fibroblasts which are abundant in oral tissue, blue light irradiation inhibited the proliferative activity of fibroblasts, like vascular smooth muscle cells. This reaction was significantly suppressed with an LED light source compared with a quartz tungsten halogen light source. These results suggest that the first target of blue light irradiation might be mitochondria in the fibroblast. In rat palatal gingiva, blue light irradiation increased the level of malondialdehyde (MDA) associated with lipid peroxidation induced by ROS. The level of MDA was inhibited by pre-administration of an antioxidant such as N-acetyl-L-cysteine (NAC). It is suggested that blue light irradiation used in dental treatment causes disorders of oxidative stress even at the biological level. Fortunately, it is confirmed that the cytotoxicity of blue light can be protected by pre-administering antioxidants such as NAC. Therefore, administration of antioxidants is necessary to protect the oral tissue from oxidative stress induced by blue light irradiation before various dysfunctions occur.
Practice　： Dentistry
Keywords　：