アブストラクト（50巻suppl号：神奈川歯学）

神奈川歯学

Japanese

Title　： 災害時ストレス性精神疾患に対する咀嚼器官活性化の有効性の検討
Subtitle　： 総説
Authors　： 笹栗健一1, 成松侑梨1, 山田健太朗2, 河田俊嗣1, 山本利春2
Authors（kana）　：
Organization　： 1神奈川歯科大学口腔科学講座歯科矯正学, 2神奈川歯科大学口腔科学講座高次脳機能学
Journal　： 神奈川歯学
Volume　： 50
Number　： suppl
Page　： 42-45
Year/Month　： 2015 /
Article　： 報告
Publisher　： 神奈川歯科大学学会
Abstract　： 「抄録」本研究は, ストレス下における咀嚼器官の活性化が情動反応の中枢である扁桃体と, その扁桃体からの投射を受けストレスの身体応答に対して大きな役割を果たしている視床下部室傍核におよぼす脳内機構を解明し, 将来的に災害時やその後に発生するストレス性精神疾患に対し, 咀嚼器官を活用した新しい緩和アプローチを確立するための基礎的研究を行うことを目的とした. その結果, ストレスにより増強された視床下部室傍核のphosphorylated-extracellular signal-regulated kinase 1/2(p-ERK1/2)の発現は, ストレス下での咀嚼器官からの求心性入力の増大により減弱するが, 片側性に扁桃体機能を障害したラットでは, 同側視床下部室傍核のp-ERK1/2発現減弱効果が抑制した. このことから, ストレス下における咀嚼器官からの求心性入力は, 扁桃体を介し視床下部室傍核でのストレス応答変化を調節していることが明らかとなった.
Practice　： 歯科学
Keywords　： ストレス, p-ERK1/2, 扁桃体, 視床下部室傍核

English

Title　： Activation of masticatory organs implies ameliorative effects on the disaster-induced mental disorders
Subtitle　：
Authors　： Kenichi SASAGURI1, Yuri NARIMATSU1, Kentaro YAMADA2, Toshitsugu KAWATA1, Toshiharu YAMAMOTO2
Authors（kana）　：
Organization　： 1Department of Oral Science, Orthodontic Division, Kanagawa Dental University Graduate School, 2Department of Oral Science, Brain Functions and Neuroscience Division, Kanagawa Dental University Graduate School
Journal　： Kanagawa Shigaku
Volume　： 50
Number　： suppl
Page　： 42-45
Year/Month　： 2015 /
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The present study was aimed to clarify the cerebral mechanism of the stress-attenuating effect of the activation of masticatory organ under stress situation by focusing on the relationship between the amygdala, which is the center in charge of regulating emotions, and the hypothalamus, which is a center affiliated with the autonomic nervous system as well as governing the response to stress in a homeostasis. In future, the results of the present study propose the act of masticatory organ as simple and easy stress-attenuating tool for stress-related mental illness after disaster victims. As results, the expression of phosphorylated-extracellular signal-regulated kinase 1/2 (p-ERK1/2), such as one of the stress marker, was enhanced by stress in the hypothalamus paraventricular nucleus (PVN). However, Stress-induced expression of pERK1/2 in PVN were decreased by simultaneously activation of masticatory organ during stress. Furthermore, this phenomenon was not observed in the side of the unilaterally destroyed amygdala by kainic acid. Namely, afferent input from the activation of masticatory organ was regulates the expression of pERK1/2 in PVN through the amygdala. The results of this study suggest that activation of masticatory organ may be useful in the prevention of systemic diseases such as depression and heart diseases, which are believed to have developed at an increasing rate among disaster victims.
Practice　： Dentistry
Keywords　： p-ERK1/2