アブストラクト（53巻1/2号：神奈川歯学）

神奈川歯学

English

Title　： Antimicrobial activity and inhibitory effect of alveolar bone loss of toothpaste containing a natural plant extract
Subtitle　： Mini Review
Authors　： Takenori SATO1), Kiyoko WATANABE2), Haruka SASAKI2), Hiroko HIRAMINE3), Seiji GODA1), Nobushiro HAMADA2)
Authors（kana）　：
Organization　： 1)Division of Oral Molecular and Cellular Biochemistry, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 2)Division of Microbiology, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 3)Department of Highly Advanced Stomatology, Graduate School of Dentistry, Kanagawa Dental University
Journal　： Kanagawa Shigaku
Volume　： 53
Number　： 1/2
Page　： 40-44
Year/Month　： 2018 / 12
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Oral microorganisms are a trigger for caries and periodontal diseases. Several agents have been formulated into toothpastes to prevent caries and periodontal diseases. Cetylpyridinium chloride (CPC), a cationic quaternary ammonium compound, has great antimicrobial activity and inhibits biofilm formation. Pycnogenol(R) (PYC), a natural standardized extract from the bark of the French maritime pine tree, has strong antioxidant and anti-inflammatory profiles. This mini review focused on the antimicrobial activity and the inhibitory effect of alveolar bone loss by the toothpaste containing PYC and CPC. The antimicrobial activity of a toothpaste containing PYC and CPC were determined by using an agar diffusion test. The inhibitory effect of alveolar bone resorption by toothpaste administration were evaluated by using in the aged rat model. The toothpaste showed great antimicrobial activity against Streptococcus mutans, Actinomyces naeslundii and Porphyromonas gingivalis. The level of alveolar bone loss in rats administered with the toothpaste containing PYC and CPC was significantly lower than that in sham-infected control (p < 0.05). The number of osteoclasts at the maxillary molars was significantly decreased by the administration of the toothpaste (p < 0.05). The results indicated that PYC and CPC suppress bacterial growth and osteoclastogenesis in age-related changes. These results suggest that toothpaste containing PYC and CPC provide better oral health and prevent the development of periodontal diseases. PYC may be an important natural ingredient for the preservation of oral health.
Practice　： Dentistry
Keywords　： Alveolar bone loss, Toothpaste, Pycnogenol, Cetylpyridinium