アブストラクト（53巻1/2号：神奈川歯学）

神奈川歯学

English

Title　： Antimicrobial activity of a novel silane coupling agent having quaternary ammonium salt using polymicrobial biofilm model
Subtitle　： Mini Review
Authors　： Kaori MIYAKE-AOKI1), Kiyoshi TOMIYAMA2), Katsura OHASHI1), Yuka KAMEYAMA1), Yuuki WADA1), Tota SHIMIZU3), Norio YOSHINO4), Yoshiharu MUKAI2), Nobushiro HAMADA3), Toshio TERANAKA2), Tomotaro NIHEI1)
Authors（kana）　：
Organization　： 1)Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 2)Department of Oral Interdisciplinary Medicine (Restorative Dentistry) Graduate School of Dentistry Kanagawa Dental University, 3)Department of Oral Interdisciplinary Medicine (Prosthodontics & Oral Implantology) Graduate School of Dentistry Kanagawa Dental University, 4)Department of Industrial Chemistry, Tokyo University of Science
Journal　： Kanagawa Shigaku
Volume　： 53
Number　： 1/2
Page　： 54-55
Year/Month　： 2018 / 12
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The purpose of investigation was to evaluate the antimicrobial activity of a novel quaternary ammonium silane coupling agent, N-allyl-N-decyl-N-methyl-N-trimethoxysilylpropylammonium iodide (10-I), against early-stage biofilms using a polymicrobial biofilm model that simulates oral plaque-like biofilm formation on a solid phase. The cover glasses immersed in 10-I for 1 hour to modify the surface. The polymicrobial biofilm was prepared as reported by Exterkate et al., we calculated colony forming unit (CFU). CFU of the 10-I group was about 80% lower than that of the control group, demonstrating strong antimicrobial activity. The surface modification with 10-I represents an effective means for treatment of oral indigenous bacteria-related dental diseases found in the elderly and immunocompromised people and possible systemic complications such as aspiration pneumonia.
Practice　： Dentistry
Keywords　： Antimicrobial silane coupling agent, Contact-active antimicrobial effect, Polymicrobial biofilm model